Results 71 to 80 of about 1,537,491 (304)

Comparing routine inpatient data and death records as a means of identifying children and young people with life limiting conditions [PDF]

, 2017
Background Recent estimates of the number of children and young people with life limiting conditions derived from routine inpatient data are higher than earlier estimates using death record data. Aim To compare routine inpatient data and death records as
Baum D, Chambers L, Cochrane H, Fraser LK, Health and Social Care Information Centre, Lorna K Fraser, Noble M, Office for National Statistics (ONS), Office for National Statistics (ONS), Office for National Statistics (ONS), Office for National Statistics and Mortality Statistics, Platt L., Stuart Jarvis, World Health Organization (WHO)   +13 more
core   +1 more source

Confiabilidade da declaração de causa básica de mortes infantis em região metropolitana do sudeste do Brasil Reliability of the medical certificates of underlying cause of infant deaths in a metropolitan region of southeastern Brazil

Revista de Saúde Pública, 1994
A partir de dados coletados para um estudo sobre a mortalidade infantil na região metropolitana de Belo Horizonte, MG, Brasil, foi selecionada uma amostra aleatória de óbitos infantis ocorridos em 1989, para avaliar a concordância da causa básica de ...
Elisabeth F. Mendonça, Eugênio M.A. Goulart, José A.D. Machado   +2 more
doaj   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source

We only die once... but from how many causes? [PDF]

, 2016
Analysing causes of death provides a betterunderstanding of long-term mortality trends. InFrance, the death certificates completed by physiciansgenerally mention several causes of death (2.4 onaverage in 2011).
Barbieri, M, Demuru, E, Denissov, G, Désesquelles, A, Egidi, V, Frova, L, Gamboni, A, Goldberger, N, Grundy, E, Marshall, C, Meslé, F, Pappagallo, M, Pechholdova, M, Sakkeus, L   +13 more
core  

Validade das informações ocupação e causa básica em declarações de óbito de Botucatu, São Paulo Validity of information on occupation and principal cause on death certificates in Botucatu, São Paulo

Cadernos de Saúde Pública, 1999
O objetivo deste trabalho é estudar a validade das informações sobre ocupação habitual e causa básica em declarações de óbito (DO) de moradores de Botucatu falecidos nesta cidade.
Ricardo Cordeiro, Eduardo Rommel Olivencia Peñaloza, Chrystiano Fonseca Cardoso, Daniela Barros Cortez, Eric Kakinami, Jacques José Gomes de Souza, Maria Tereza de Moraes Souza, Ricardo Augusto Fernandes, Rodrigo Fernando Guercia, Tarso Adoni   +9 more
doaj   +1 more source

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core  

Causas múltiples de muerte

Revista Cubana de Higiene y Epidemiología, 1998
Se presenta un estudio de causas múltiples de muerte, en la población cubana de 1 año y más de edad. La información se obtuvo de una muestra de 2 036 defunciones ocurridas durante 4 meses consecutivos en 22 municipios del país.
Norma Eneida Ríos Massabot, Ana Consuelo Mesa Machado, Arnaldo Tejeiro Fernández   +2 more
doaj  

PARP inhibition and pharmacological ascorbate demonstrate synergy in castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon, Peter T. Gallagher, Orly I. Richter, Neermala Poudel Neupane, Amy C. Mandigo, Jennifer J. McCann, Emanuela Dylgjeri, Irina Vasilevskaya, Christopher McNair, Channing J. Paller, Wm. Kevin Kelly, Karen E. Knudsen, Matthew J. Schiewer, Ayesha A. Shafi   +13 more
wiley   +1 more source