Results 81 to 90 of about 1,552,146 (293)

Validade das informações ocupação e causa básica em declarações de óbito de Botucatu, São Paulo Validity of information on occupation and principal cause on death certificates in Botucatu, São Paulo

Cadernos de Saúde Pública, 1999
O objetivo deste trabalho é estudar a validade das informações sobre ocupação habitual e causa básica em declarações de óbito (DO) de moradores de Botucatu falecidos nesta cidade.
Ricardo Cordeiro, Eduardo Rommel Olivencia Peñaloza, Chrystiano Fonseca Cardoso, Daniela Barros Cortez, Eric Kakinami, Jacques José Gomes de Souza, Maria Tereza de Moraes Souza, Ricardo Augusto Fernandes, Rodrigo Fernando Guercia, Tarso Adoni   +9 more
doaj   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

β-Amyloid peptides induce mitochondrial dysfunction and oxidative stress in astrocytes and death of neurons through activation of NADPH oxidase [PDF]

, 2004
β-Amyloid (βA) peptide is strongly implicated in the neurodegeneration underlying Alzheimer's disease, but the mechanisms of neurotoxicity remain controversial. This study establishes a central role for oxidative stress by the activation of NADPH oxidase
Abramov, A.Y., Canevari, L., Duchen, M.R.   +2 more
core  

Changes in the Proportion of Deaths Attributable to Ill-defined Causes in Bahrain from 2000 to 2020

Saudi Journal of Medicine and Medical Sciences
Background: Mortality data are used to assess the development and implementation of health policies, set public health priorities, and evaluate population health.
Randah R. Hamadeh, Enjy Khedr
doaj   +1 more source

Dimethyl fumarate combined with cisplatin at subcytotoxic doses sensitizes cervical cancer toward ferroptosis and apoptosis through GSH restriction and p53 (re)activation

Molecular Oncology, EarlyView.
Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano, Giuseppina Minopoli, Simona Romano, Laura Marrone, Katia Aquilano, Maria Lina Tornesello, Raffaella Faraonio   +6 more
wiley   +1 more source

Prevalence, underlying causes, and preventability of sepsis-associated mortality in US acute care hospitals [PDF]

, 2019
Importance: Sepsis is present in many hospitalizations that culminate in death. The contribution of sepsis to these deaths, and the extent to which they are preventable, is unknown.
Anderson, Deverick J, Dantes, Raymund B, Epstein, Lauren, Hamad, Yasir, Jones, Travis M, Klompas, Michael, O\u27Brien, Cara, Pande, Anupam, Rhee, Chanu, Varon, Jack, Warren, David K   +10 more
core   +1 more source

Comparing routine inpatient data and death records as a means of identifying children and young people with life limiting conditions [PDF]

, 2017
Background Recent estimates of the number of children and young people with life limiting conditions derived from routine inpatient data are higher than earlier estimates using death record data. Aim To compare routine inpatient data and death records as
Baum D, Chambers L, Cochrane H, Fraser LK, Health and Social Care Information Centre, Lorna K Fraser, Noble M, Office for National Statistics (ONS), Office for National Statistics (ONS), Office for National Statistics (ONS), Office for National Statistics and Mortality Statistics, Platt L., Stuart Jarvis, World Health Organization (WHO)   +13 more
core   +1 more source

Codificação da sepse pulmonar e o perfil de mortalidade no Rio de Janeiro, RJ

Revista Brasileira de Epidemiologia
RESUMO: Objetivo: Descrever os óbitos com menção de sepse pulmonar, medir a associação entre sepse pulmonar e pneumonia, assim como avaliar o impacto da regra de codificação no perfil de mortalidade, com a inclusão simulada do diagnóstico de pneumonia,
Bruno Baptista Cardoso, Pauline Lorena Kale   +1 more
doaj   +1 more source

Targeted modulation of IGFL2‐AS1 reveals its translational potential in cervical adenocarcinoma

Molecular Oncology, EarlyView.
Cervical adenocarcinoma patients face worse outcomes than squamous cell carcinoma counterparts despite similar treatment. The identification of IGFL2‐AS1's differential expression provides a molecular basis for distinguishing these histotypes, paving the way for personalized therapies and improved survival in vulnerable populations globally.
Ricardo Cesar Cintra, Lucca Paolo Hsu Helmich, Daniel Rodrigues de Bastos, Laura Sichero, Patrícia Savio de Araujo‐Souza, Fabio Passetti, Luisa Lina Villa   +6 more
wiley   +1 more source

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source