Results 91 to 100 of about 8,566,469 (316)
Understanding Fratelli Tutti by Understanding 'Understanding'
, 2021 Understanding is oft misunderstood as a species of knowledge in philosophy by equating it with propositional understanding. However, understanding – which was regarded as a greater cognitive achievement than knowledge even in ancient Greek philosophy – is desired more than knowledge in both science and philosophy.
openaire +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Unraveling electronic correlations in warm dense quantum plasmas
Nature CommunicationsThe study of matter at extreme densities and temperatures has emerged as a highly active frontier at the interface of plasma physics, material science and quantum chemistry with relevance for planetary modeling and inertial confinement fusion.
Tobias Dornheim +12 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Complex & Intelligent SystemsInstant delivery service has brought great convenience to our modern life. In order to improve its efficiency, multi-depot pick-up-and-delivery location routing problem with time windows (MDPDLRPTW) is proposed in this paper.
Haoyuan Lv, Ruochen Liu, Jianxia Li
doaj +1 more source
Restricted Boltzmann Machine-Based Approaches for Link Prediction in Dynamic Networks
IEEE Access, 2018 Link prediction in dynamic networks aims to predict edges according to historical linkage status. It is inherently difficult because of the linear/non-linear transformation of underlying structures.
Taisong Li +4 more
doaj +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source