Results 81 to 90 of about 4,354,150 (246)

Test Center Location Problem: A Bi-Objective Model and Algorithms

open access: yesAlgorithms
The optimal placement of healthcare facilities, including the placement of diagnostic test centers, plays a pivotal role in ensuring efficient and equitable access to healthcare services.
Mansoor Davoodi, Justin M. Calabrese
doaj   +1 more source

An Open, Pilot Study of the Understanding Words Reading Intervention Program

open access: yesSAGE Open, 2011
The aim of this study was to assess the clinical efficacy of a new reading intervention program, Understanding Words, for struggling readers in an open trial design.
Craig Wright   +3 more
doaj   +1 more source

An upstream open reading frame regulates expression of the mitochondrial protein Slm35 and mitophagy flux

open access: yesFEBS Letters, EarlyView.
This study reveals how the mitochondrial protein Slm35 is regulated in Saccharomyces cerevisiae. The authors identify stress‐responsive DNA elements and two upstream open reading frames (uORFs) in the 5′ untranslated region of SLM35. One uORF restricts translation, and its mutation increases Slm35 protein levels and mitophagy.
Hernán Romo‐Casanueva   +5 more
wiley   +1 more source

Computational Modeling of Saliency from Image Histogram

open access: yesi-Perception, 2011
Computational model of image saliency plays an important role for vision tasks such as visual search and attention modeling. We developed a computational model that captures both shape and color image saliency based on histograms.
Shijian Lu, Joo Hwee Lim
doaj   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

PyPlaque is an open-source python package for phenotypic analysis of virus plaque assays

open access: yesScientific Reports
Virological plaque assays are the primary method for quantifying infectious particles in a suspension, achieved by incubating a serial dilution of the virus with a monolayer of indicator cells.
Trina De   +2 more
doaj   +1 more source

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

open access: yesFEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva   +10 more
wiley   +1 more source

Tracking with scattering descriptor

open access: yesIET Computer Vision, 2014
This study proposes a new method to track the moving object based on undecimated scattering transform (UST). The UST removes the down‐sampling operation from the traditional scattering transform to produce a complete representation. Based on the UST, the
Xiaolin Tian   +2 more
doaj   +1 more source

Understanding Kantian Understanding [PDF]

open access: yes, 2018
Over the last decade or so philosophers have become increasingly dissatisfied with the dominant focus on the notion of knowledge in contemporary epistemology. Understanding, it has been suggested, is an important intellectual goal, often valuable over and above knowing the facts.
openaire   +2 more sources

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

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