Results 171 to 180 of about 6,656 (263)

Contrastive ecoacoustic indices: Large‐scale global soundscape characterization with contrastive inference

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Ecoacoustics mainly aims at monitoring soundscapes by means of non‐invasive protocols. Despite the widespread adoption of machine and deep learning techniques, existing ecoacoustic models predominantly rely on supervised learning and, consequently, face two primary limitations: (1) the necessity of annotated data; and (2) the restriction to ...
Yann Teytaut   +7 more
wiley   +1 more source

DeepZoo: A cost‐effective and modular sampler for ecological studies in the deep ocean

open access: yesMethods in Ecology and Evolution, EarlyView.
Abstract Understanding the structure and dynamics of deep‐ocean communities requires effective sampling of pelagic organisms in near‐bottom waters. These dispersive organisms contribute to biodiversity, connectivity and ecosystem recovery. Yet, current sampling methods remain constrained by size, cost, and depth, leaving key questions unanswered in ...
Johanna N. J. Weston   +7 more
wiley   +1 more source

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

open access: yesAllergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang   +12 more
wiley   +1 more source

Adiponectin promotes AMPA receptor trafficking and enhances excitatory synaptic transmission at hippocampal synapses via AMP‐activated protein kinase signalling

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Peripherally derived adiponectin crosses the blood–brain barrier and targets severa0l brain regions. Adiponectin receptors are highly expressed in the hippocampus, and play a pro‐cognitive role as adiponectin markedly influences the functioning of hippocampal synapses.
Alexandra Soca   +4 more
wiley   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

open access: yesBritish Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock   +9 more
wiley   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

open access: yesBritish Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton   +6 more
wiley   +1 more source

Nonlinear Attitude Control of a Spherical Underwater Vehicle. [PDF]

open access: yesSensors (Basel), 2019
Fernandez RAS   +4 more
europepmc   +1 more source

Advancing conservation breeding programs for marine invertebrates

open access: yesConservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam   +3 more
wiley   +1 more source

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