Results 161 to 170 of about 1,006,834 (242)

Deficiency of Mitochondrial Fatty Acid Enzyme, CPT1A, Underlies Airway Epithelial Barrier Dysfunction in Severe Asthma

Allergy, EarlyView.
Mitochondrial fatty acid enzyme, CPT1A, is deficient in the airway epithelium of severe asthma patients. Restoration of CPT1A expression improved epithelial barrier integrity via increasing mitochondrial respiration and ATP production in airway epithelial cells. Restoration of deficient epithelial CPT1A may represent a new treatment approach for severe
Muyun Wang, Haiyang Hu, Kun Wang, Di Wu, Ximing Liao, Jing Gao, Tian Li, Wujian Xu, Shaoyong Gao, Qiang Li, Pankaj Kumar Bhavsar, Wei Gao, Kian Fan Chung   +12 more
wiley   +1 more source

Nonlinear Attitude Control of a Spherical Underwater Vehicle. [PDF]

Sensors (Basel), 2019
Fernandez RAS, R EAP, Milosevic Z, Dominguez S, Rossi C.   +4 more
europepmc   +1 more source

Signal detection and characterisation of a novel drug–drug interaction between methadone and a synthetic cannabinoid receptor agonist

British Journal of Pharmacology, EarlyView.
Background and Purpose Little is known about how synthetic cannabinoid receptor agonist (SCRA) co‐use with other psychoactive substances may exacerbate risk of death. This study aimed to characterise the polypharmacy of deaths where SCRAs were detected at post‐mortem, investigate the cardiotoxicity of SCRAs and probe their inhibition of human ether‐a ...
Kirsten L. Rock, Louise M. Hesketh, Hongwei Cheng, Shuoqi Chen, Simon Hudson, Graeme Henderson, Jules C. Hancox, Michael J. Shattock, Michael J. Curtis, Caroline S. Copeland   +9 more
wiley   +1 more source

The c‐Src inhibitor eCF506 diminishes opioid tolerance and reduces β‐arrestin2 recruitment

British Journal of Pharmacology, EarlyView.
Morphine activation of μ receptors causes tolerance through c‐Src activation and β‐arrestin2 recruitment. c‐Src inhibition or degradation reduces β‐arrestin2 recruitment, μ receptor endocytosis, while causing receptor upregulation, all likely contributing to reduced morphine tolerance.
Samuel Singleton, Fraser Nunn, Erika Lace, Álvaro Lorente‐Macías, Rachel Toth, Asier Unciti‐Broceta, Tim G. Hales   +6 more
wiley   +1 more source

Advancing conservation breeding programs for marine invertebrates

Conservation Biology, EarlyView.
Abstract In the face of ecosystem change and biodiversity loss caused by climate change and other stressors, conservation breeding, or captive breeding, with the aim of reintroduction for wild population recovery, is an emerging tool for preventing species’ extinction and rehabilitating ecosystems.
Elora H. López‐Nandam, Bart Shepherd, Kylie Lev, Rebecca Albright   +3 more
wiley   +1 more source

Animal Teachers: Nonhuman Pedagogy and the Question of Deceit

Educational Theory, EarlyView.
Abstract Animals as “teachers” of human children and adults is a recurring theme in children's literature, in anthropological accounts of “feral children,” as well as in contemporary practices of animal‐assisted pedagogy, philosophical research, wildlife documentaries, and popular culture.
Helena Pedersen
wiley   +1 more source

ALOX15 mediates thrombin‐induced myristoylation, trafficking, and interaction of protease‐activated receptors, leading to platelet activation and hemostasis

The FEBS Journal, EarlyView.
The role of PARs in platelet function is fairly known; however, the underlying mechanisms are not fully understood. We report that thrombin myristoylates PAR4 in mouse platelets and PAR1 and PAR4 in human platelets, facilitating their membrane transport and interaction, leading to PAR3/4 heterodimers in mice and PAR1/4 heterodimers in humans.
Suresh Govatati, Chandra Sekhar Yadavalli, Md Monirul Hoque, Swapna Thota, Gadiparthi N. Rao   +4 more
wiley   +1 more source

Uncalibrated Visual Servoing for Underwater Vehicle Manipulator Systems with an Eye in Hand Configuration Camera. [PDF]

Sensors (Basel), 2019
Li J, Huang H, Xu Y, Wu H, Wan L.
europepmc   +1 more source

Weathering the Storm: Effects of a Hurricane‐Induced Thermal Disturbance on a Juvenile Atlantic Halibut (Hippoglossus hippoglossus) Hotspot in Nova Scotia, Canada

Fisheries Oceanography, EarlyView.
ABSTRACT Atlantic Halibut has recently become the most valuable groundfish in Atlantic Canada following population recovery, and the benthic habitat characteristics of their aggregation areas have been identified as a key outstanding ecological knowledge gap for the species. In 2022, during a multi‐year acoustic tracking study in a key juvenile hotspot
Elizabeth M. T. Bateman, Danni L. Harper, Sarah J. Baldwin, Ellen M. Weise, Daniel E. Ruzzante, Cornelia E. den Heyer, Michael J. W. Stokesbury   +6 more
wiley   +1 more source

A Novel Approach for Underwater Vehicle Localization and Communication Based on Laser Reflection. [PDF]

Sensors (Basel), 2019
Wu S, Zhou P, Yang C, Zhu Y, Zhi H.
europepmc   +1 more source