Results 141 to 150 of about 213,377 (343)

Malnutrition prevalence study in the 2-6 years old children in Kerman rural kindergartens, Kerman, Iran, 2012 [PDF]

Journal of Kerman University of Medical Sciences, 2017
Introduction: Infants and young children are the most vulnerable group to malnutrition. Malnutrition can cause child growth disorders. Child growth measurement is a basic instrument to measure the child malnutrition. This study was conducted to determine
Faride Doostan, Mina Tabatabaei, Saba Loloei   +2 more
doaj  

ATF4‐mediated stress response as a therapeutic vulnerability in chordoma

Molecular Oncology, EarlyView.
We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone, James Dunford, Eleanor Calcutt, Vicki Gamble, Filiz Senbabaoglu Aksu, Lorena Ligammari, Georgina Wherry, Giorgia Gaeta, John C. Christianson, Adrienne M. Flanagan, Udo Oppermann, Adam P. Cribbs   +11 more
wiley   +1 more source

Prevalence of underweight, overweight, and obesity in children and adolescents with type 1 diabetes: Data from the international SWEET registry [PDF]

, 2018
Claudio Maffeis, Niels Birkebæk, М.М. Константинова, Anke Schwandt, Andriani Vazeou, Kristina Casteels, Sujata Jali, Catarina Limbert, Austė Pundziūtė-Lyckå, Péter Tóth‐Heyn, Carine de Beaufort, Zdenĕk Šumnı́k, Valentino Cherubini, Jannet Svensson, Danièle Pacaud, Christina Kanaka‐Gantenbein, Shlomit Shalitin, Nataša Bratina, Ragnar Hanås, G. Todd Alonso, Poran Luxmi, Ana Lúcia Bender Pereira, Marco Marigliano, The SWEET Study Group   +23 more
openalex   +1 more source

Developing evidence‐based, cost‐effective P4 cancer medicine for driving innovation in prevention, therapeutics, patient care and reducing healthcare inequalities

Molecular Oncology, EarlyView.
The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg, Joachim von Braun, Julio Celis, Anton Berns, Michael Baumann, Tit Albreht, Nancy Abou‐Zeid, Vanderlei Bagnato, Christian Brandts, Chien‐Jen Chen, Massimiliano di Pietro, Manjit Dosanjh, Thomas Dubois, Alexander Eggermont, Angelika Eggert, Ingemar Ernberg, Sara Faithfull, Johannes Förner, Stefan Fröhling, Manuel Heitor, Leroy Hood, Wei Jiang, Bengt Jönsson, Ravi Kannan, Maria Leptin, Su Li, Peter Lindgren, Douglas Lowy, Jun Ma, Alex Markham, Péter Nagy, Simon Oberst, M. Iqbal Parker, Danielle Rodin, Kevin Ryan, Joachim Schüz, Richard Sullivan, Josep Tabernero, Peter Turkson, Oliver Várhelyi, Harold Varmus, Chijie Wang, Elisabete Weiderpass, Nils Wilking   +43 more
wiley   +1 more source

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Contextual determinates of under-five malnutrition in mining communities: a critical review of nutrition interventions for optimal impact

Frontiers in Public Health
PurposeMalnutrition continues to be a widespread and critical public health issue, yet there is a lack of comprehensive evidence synthesizing empirical findings and assessing the practicality of nutrition interventions in diverse contexts.
Herbert Tato Nyirenda, David Mulenga, Hilda Nyambe-Silavwe   +2 more
doaj   +1 more source

Therapeutic strategies for MMAE‐resistant bladder cancer through DPP4 inhibition

Molecular Oncology, EarlyView.
We established monomethyl auristatin E (MMAE)‐resistant bladder cancer (BC) cell lines by exposure to progressively increasing concentrations of MMAE in vitro. RNA sequencing showed DPP4 expression was increased in MMAE‐resistant BC cells. Both si‐DPP4 and the DPP4 inhibitor sitagliptin suppressed the viability of MMAE‐resistant BC cells.
Gang Li, Shuichi Tatarano, Hirofumi Yoshino, Saeki Saito, Mitsuhiko Tominaga, Junya Arima, Ikumi Fukuda, Takashi Sakaguchi, Ryosuke Matsushita, Yasutoshi Yamada, Hideki Enokida   +10 more
wiley   +1 more source

Short Sleep Duration is Inversely Associated with the Prevalence of Underweight in a Young Japanese Population

Nature and Science of Sleep
Sho Ishikawa,1 Shinya Furukawa,2 Teruki Miyake,1 Osamu Yoshida,1 Yoshimasa Murakami,1 Ayumi Kanamoto,1 Masumi Miyazaki,1 Akihito Shiomi,1 Hironobu Nakaguchi,3 Hironobu Saneto,1 Kaori Marui,1 Masahito Kokubu,1 Yuki Numata,1 Mitsuhito Koizumi,1 Aki Kato,2 ...
Ishikawa S, Furukawa S, Miyake T, Yoshida O, Murakami Y, Kanamoto A, Miyazaki M, Shiomi A, Nakaguchi H, Saneto H, Marui K, Kokubu M, Numata Y, Koizumi M, Kato A, Kusumoto K, Kumagi T, Matsuura B, Hiasa Y   +18 more
doaj  

Decoding India’s Child Malnutrition Puzzle: A Multivariable Analysis Using a Composite Index

Children
Background: This study examines the levels and predictors of malnutrition in Indian children under 5 years of age. Methods: Composite Index of Anthropometric Failure was applied to data from the India National Family Health Survey 2019–2021.
Gulzar Shah, Maryam Siddiqa, Padmini Shankar, Indira Karibayeva, Amber Zubair, Bushra Shah   +5 more
doaj   +1 more source

Recurrent cancer‐associated ERBB4 mutations are transforming and confer resistance to targeted therapies

Molecular Oncology, EarlyView.
We show that the majority of the 18 analyzed recurrent cancer‐associated ERBB4 mutations are transforming. The most potent mutations are activating, co‐operate with other ERBB receptors, and are sensitive to pan‐ERBB inhibitors. Activating ERBB4 mutations also promote therapy resistance in EGFR‐mutant lung cancer.
Veera K. Ojala, Sini Ahonen, Sara Peltola, Aura Tuohisto‐Kokko, Olaya Esparta, Peppi Suominen, Anne Jokilammi, Iman Farahani, Deepankar Chakroborty, Nikol Dibus, Steffen Boettcher, Tomi T. Airenne, Mark S. Johnson, Lisa D. Eli, Klaus Elenius, Kari J. Kurppa   +15 more
wiley   +1 more source