Results 31 to 40 of about 27,182,131 (255)

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

open access: yesFEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen   +8 more
wiley   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

open access: yesAdvanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar   +2 more
wiley   +1 more source

The Effectiveness of Android Application as a Student Aid Tool in Understanding Physics Project Assignments

open access: yesJurnal Pendidikan IPA Indonesia, 2019
Indonesian students are addicted to using gadgets, which unfortunately brings negative impacts. Using the gadget for a long duration will undoubtedly affect the quality of students if it is not directed to appropriate and beneficial use.
I. Safitri   +3 more
doaj   +1 more source

Commission on Security and Cooperation in Europe (Helsinki Commission): Briefing on Truth, Reconciliation, and Healing Toward a Unified Future Thursday, July 18, 2019

open access: yesHealth Equity, 2021
Chairman Hastings, Chairman Wicker, commission members, and our audience, thank you for holding this important briefing. I am honored to testify on methodologies that can unify and heal societies across the globe that have been divided by war, genocide,
doaj   +1 more source

Undone Science and Smart Cities: Civil Society Perspectives on Risk and Emerging Technologies [PDF]

open access: yes, 2021
AbstractThis study contributes to the analysis of civil society and knowledge by examining mobilizations by civil society organizations and grassroots networks in opposition to wireless smart meters in the United States. Three types of mobilizations are reviewed: grassroots anti-smart-meter networks, privacy organizations, and organizations that ...
openaire   +1 more source

Thermodynamic Pathways of Nonequilibrium Solidification in Wire‐Arc Additive Manufacturing Fe‐Based Multicomponent Alloy Structures

open access: yesAdvanced Engineering Materials, EarlyView.
Geometry‐driven thermal behavior in wire‐arc additive manufacturing (WAAM) influences microstructural evolution during nonequilibrium solidification of a chemically complex Fe–Cr–Nb–W–Mo–C nanocomposite system. By comparing different deposits configurations, distinct entropy–cooling rate correlations, segregation, and carbide evolution are revealed ...
Blanca Palacios   +5 more
wiley   +1 more source

A Simplified Laminar Flow Model for the Pultrusion of Glass Fiber/Polyethylene Terephthalate Commingled Yarns

open access: yesAdvanced Engineering Materials, EarlyView.
A simplified thermoplastic pultrusion model is developed to predict thermal fields in glass fiber/polyethylene terephthalate (GF/PET) composites with reduced computational cost. By combining effective material homogenization, validation against literature data, and Gaussian‐process‐based optimization, the study reveals how heating limits, pulling speed,
Elder Soares   +3 more
wiley   +1 more source

Comparison of Triply Periodic Minimal Surface Energy Absorbers Under Uniaxial Compressive Loading

open access: yesAdvanced Engineering Materials, EarlyView.
This study investigates LCD 3D printed Triply Periodic Minimal Surface (TPMS) structures as mechanical energy absorbers. By comparing various base designs and layered combinations under uniaxial compression, it identifies that a Diamond‐Gyroid sandwich structure offers superior performance.
Sergej Grednev   +2 more
wiley   +1 more source

Happy Catastrophe: Recent Progress in Analysis and Exploitation of Elastic Instability

open access: yesFrontiers in Applied Mathematics and Statistics, 2019
A synthesis of recent progress is presented on a topic that lies at the heart of both structural engineering and non-linear science. The emphasis is on thin elastic structures that lose stability subcritically—without a nearby stable post-buckled state—a
Alan R. Champneys   +9 more
doaj   +1 more source

Entropy‐Driven Design of Low‐Melting‐Point Alloys via Compositionally Complex Strategy

open access: yesAdvanced Engineering Materials, EarlyView.
Conventional low‐melting‐point alloys (LMPAs) are limited by a narrow compositional space and inherent property trade‐offs. This review presents an entropy‐driven design strategy that overcomes these limitations, ushering in a new class of low‐melting‐point compositionally complex alloys (LMCCAs).
Yinghui Shang   +6 more
wiley   +1 more source

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