Results 141 to 150 of about 5,842,410 (204)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Overview of stream restoration technology: State of the science

ecosystem MANAGEMENT AND RESTORATION Technology News from the Ecosystem Management and Restoration Research Program October 1999 Overview of stream restoration technology: State of the science by J.
Engineer Research and Development Center (U.S.); Ecosystem Management and Restoration Research Program (U.S.);
core  

Beyond species means - the intraspecific contribution to global wood density variation. [PDF]

New Phytol
Fischer FJ, Chave J, Zanne A, Jucker T, Fajardo A, Fayolle A, de Lima RAF, Vieilledent G, Beeckman H, Hubau W, De Mil T, Wallenus D, Aldana AM, Alvarez-Dávila E, Alves LF, Apgaua DMG, Arcanjo F, Bastin JF, Bilous A, Birnbaum P, Blyshchyk V, Borah J, Boukili V, Camarero JJ, Casas L, Cazzolla Gatti R, Chambers JQ, Fabiano EC, Choat B, Conti G, Cornwell W, Dar JA, Das AK, Dobler M, Dougabka D, Edwards DP, Evans R, Falster D, Fearnside P, Flores O, Fyllas N, Gérard J, Goodman RC, Guibal D, Henao-Diaz LF, Hervé V, Hietz P, Homeier J, Ibanez T, Ilic J, Jansen S, Kalita RM, Kenzo T, Kindermann L, Kothandaraman S, Kotowska M, Kubota Y, Langbour P, Lawson J, de Lima ALA, Link RM, Linstädter A, López R, Macinnis-Ng C, Magnago LFS, Martin AR, Matheny AM, McCarthy JK, Miller RB, Nath AJ, Nelson BW, Njana M, Nogueira EM, Oliveira A, Oliveira R, Olson M, Onoda Y, Paul K, Piotto D, Radtke P, Razafindratsima O, Ramananantoandro T, Read J, Richardson S, de la Riva EG, Rodríguez-Reyes O, Rolim SG, Rolo V, Rosell JA, Salguero-Gómez R, Santini NS, Schuldt B, Schwendenmann L, Sellin A, Staples T, Stevenson PR, Sundarapandian S, van der Sande MT, Thibaut B, Tng DYP, Torezan JMD, Villanueva B, Weiskittel A, Wells J, Wright SJ, Zieminska K.   +105 more
europepmc   +1 more source

Onasemnogene Abeparvovec in Patients With SMA: Interim Results of the RESTORE Registry in Japan

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective There are limited real‐world data regarding the safety and effectiveness of onasemnogene abeparvovec (OA; Zolgensma) infusion, a one‐time gene replacement therapy, for Japanese patients with spinal muscular atrophy (SMA). We aimed to improve understanding of the real‐world outcomes for OA in Japan.
Kayoko Saito, Kamal Benguerba, Ken Tsuchida, Kazushige Yazawa, Isao Tsumiyama, Hiromitsu Kayama, Sandra P. Reyna, Farid Khan, Richard S. Finkel   +8 more
wiley   +1 more source

Physiological roles of lignins - tuning cell wall hygroscopy and biomechanics. [PDF]

New Phytol
Pesquet E, Cesarino I, Kajita S, Pawlowski K.   +3 more
europepmc   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu, Changgeng Song, Dianwei Wu, Xiaoqian Niu, Jianmin Hao, Lijuan Liu, Xiaogang Kang, Wen Jiang   +7 more
wiley   +1 more source

Kinetic and Thermodynamic Characteristics of Torrefied Acer palmatum. [PDF]

ACS Omega
Lu A, Song Y, Wang D, Liao G, Zheng B, Liu P, Lei T.   +6 more
europepmc   +1 more source

Unsuccessful introduced biocontrol agents can act as pollinators of invasive weeds: Bitou Bush (Chrysanthemoides monilifera ssp. rotundata) as an example. [PDF]

Ecol Evol, 2017
Gross CL, Whitehead JD, Silveira de Souza C, Mackay D.   +3 more
europepmc   +1 more source

Validation of a Cellular Imaging‐Based Method as a Potential Biomarker for SPG4 Hereditary Spastic Paraplegia

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Hereditary Spastic Paraplegia (HSP) comprises a group of rare genetic diseases characterized by length‐dependent axonal degeneration of the corticospinal tracts and dorsal columns, whose main clinical feature is spastic gait. Pathogenic variants in the SPG4 gene cause Spastic Paraplegia Type 4 (SPG4‐HSP), the most common form of HSP.
Gaia Fattorini, Valerio Licursi, Gianmarco Dalla Zanna, Flavio Dal Canto, Melissa Barghigiani, Nunzio Setola, Salvatore Rossi, Antonio Funcis, Filippo M. Santorelli, Gabriella Silvestri, Carlo Casali, Francesca Sardina, Cinzia Rinaldo   +12 more
wiley   +1 more source

Instant Futures: an experimental study of the imagination of alternative near futures thanks to science fiction. [PDF]

Integr Psychol Behav Sci
Kloetzer L, Kloetzer L.
europepmc   +1 more source