Results 31 to 40 of about 170,574 (301)
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
2023 OECD/IDB Digital Government Index of Latin America and the Caribbean: Results and Key Findings [PDF]
This paper presents the main findings of the 2023 edition of the OECD/IDB Digital Government Index (DGI) for Latin America and the Caribbean (LAC), which benchmarks the efforts made by 23 governments in the region to establish the foundations necessary ...
Inter-American Development Bank
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Dementia stats down but postcode lottery drives uneven care [PDF]
, 2013 First paragraph: Dementia has been described as a ticking time bomb, with the number of those affected predicted to double in the next two decades. But a new study suggests that the prevalence of people withdementia in the UK has actually fallenover the ...
Andrews, June
core
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Journal of Indian and Asian StudiesSince the onset of the twenty-first century, India has initiated various social welfare programs to provide social protection for the people who have been marginalized from the formal social safety net.
JONGWAN BAIK
doaj +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
Uneven and combined development
, 2017 Uneven and combined development. Regional Studies. The concept of uneven and combined development (U&CD) interprets dynamic historical change and comparative geographical differentiation in terms of the co-existence of tendencies towards differentiation ...
Weidong Liu (444731) +1 more
core +2 more sources
Trade, accumulation, and uneven development [PDF]
Journal of Development Economics, 1981 This paper develops a two-country model of capital accumulation and growth where the industrial sector exhibits increasing returns to scale. It shows that ‘uneven development’ IS a necessary outcome in such a model: an initial discrepancy in capital-!abor ratios between the two countries will cumulate over time, leading to the division of the world ...
openaire +2 more sources
The Uses and Misuses of Uneven and Combined Development: An Anatomy of a Concept
, 2009 A central concern of much contemporary Marxist scholarship in international relations (IR) is to internally relate global capitalism and the state system without reducing one of these systems to an epiphenomenon of the other.
Allinson, J.C., Anievas, A.
core +1 more source