Results 41 to 50 of about 4,536 (249)

Finding novel vulnerabilities of hypomorphic BRCA1 alleles

Molecular Oncology, EarlyView.
Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder, Klaas de Lint, Hồ Mỹ Phúc Võ, Mariana M. Góis, Rosalie A. Kampen, Marta San Martin Alonso, Ilse Nootenboom, Veronica Garzero, Tiemen J. Wendel, Rob M. F. Wolthuis, Sylvie M. Noordermeer   +10 more
wiley   +1 more source

Why human connection is the true metric of research success

FEBS Open Bio, EarlyView.
Human‐centred mentorship can be shaped by mentor attributes, actions, intrinsic drive and career ambition. Drawing on reflections across Singapore and France, as well as workshop insights from FEBS‐IUBMB ENABLE 2024, this article shows that human‐centred mentorship creates the conditions for sustainable growth, well‐being and retention in research ...
Timothy Lin Yun Tan, Mattias Wei Ren Kon, Xavier Coumoul, Fun Man Fung   +3 more
wiley   +1 more source

Study on Application of Reinforcement Measures for Spillway Foundation on Thick Collapse Accumulation Body

Renmin Zhujiang, 2020
The foundation of spillway in the accumulation body is characterized by low bearing capacity,poor stability and large and uneven settlement due to the properties of an accumulation body.In particular,the bottom plate cracking and staggering along the ...
WANG Jun, NING Yu, HUANG Qingfu
doaj  

Tailored Hierarchical Porous Copper Architectures via Three Dimensional Printing and Pressure‐less Sintering for Next‐Generation Lithium‐Metal Batteries

Advanced Engineering Materials, EarlyView.
A hierarchical porous copper current collector is fabricated via three‐dimensional printing combined with pressureless sintering to stabilize lithium metal anodes. The interconnected architecture lowers local current density, guides uniform Li deposition within pores, and suppresses dendrite growth.
Alok Kumar Mishra, Mukul Shukla
wiley   +1 more source

Failure Modes and Quantitative Evaluation Methods for Uneven Settlement of Large Storage Tanks

Shiyou huagong gaodeng xuexiao xuebao
With the development of large-scale storage tanks,structural safety issues such as foundation settlement and structural deformation that affect the operation of large storage tanks have increasingly become the focus of equipment management and inspection
Baoyu LIU, Shuo YAN, Xu ZHANG, Liang DU, Xiushan SHI, Shi WANG, Yunxiu MA, Jian LI   +7 more
doaj   +1 more source

Microstructure Reconstruction in Battery Electrodes Using Machine Learning Based on Low‐Voltage Focused Ion Beam–Scanning Electron Microscopy Tomography Images

Advanced Engineering Materials, EarlyView.
Low‐voltage FIB‐SEM tomography combined with a image preprocessing pipeline improves phase contrast and enables reliable machine‐learning segmentation of conductive networks in lithium‐ion battery electrodes. Structural descriptors are extracted from segmented images, done semimanually and automated, and compared.
Lisa Beran, Vincent Nebel, Dominik Perius, Kshitij Kumar, Yannis Heim, Laura Bies, Tobias Kraus   +6 more
wiley   +1 more source

Research on the Effect of Uneven Proppant Settlement on Well Productivity in Stimulated Reservoir

IOP Conference Series: Earth and Environmental Science, 2021
Abstract The characteristics of proppant tarnsportation, settlement and distribution in fractures are of great significance to the effectiveness of complex fractures, as well to investigate the shale reservoir stimulation volume and productivity evaluation.
Tengfei Hou, Changkun Cheng, Yan Qiao, Youyu Wan, Tingsong Xiong, Shiduo Liu, Yang Zhang, Yu Ye, Bin Guo, Guoqing Wang, Guiqi Xie, Youming Liu   +11 more
openaire   +1 more source

Transfer Printing and Reconfiguration of Soft Electronics Using Digital Microfluidics and Laser Machining

Advanced Functional Materials, EarlyView.
This paper presents a digital microfluidics‐based technique for transferring and reconfiguring soft nanomembranes. Laser‐machined nanothin membranes are picked up, transported, and aligned via tailored surface tension and the actuation of water droplets, enabling the development of flexible electronics, the integration of functional materials on 3D ...
Quang Anh Nguyen, Chi Cong Nguyen, Tran Bach Dang, Phuoc Thien Phan, Jordan Thorpe, Michael Listyawan, Nhat Minh Doan, Sinuo Zhao, Hongru Chen, Trung Thien Hoang, Mingsheng Xu, Jisheng Han, Thanh Nho Do, Adam Hill, Timothée Mouterde, Hoang‐Phuong Phan   +15 more
wiley   +1 more source

Use of Foamed Cement Banking for Reducing Expressways Embankment Settlement

Applied Sciences, 2021
Expressways are often built on soft ground, the foundation of which is not processed adequately during the construction period. Consequently, the traffic safety and embankment stability will be seriously affected due to uneven settlement.
Yuedong Wu, Hui Liu, Jian Liu
doaj   +1 more source

Integrated Field‐Free SOT Domain‐Wall Synapses and MTJ Stochastic Neurons for Hardware Boltzmann Machines

Advanced Functional Materials, EarlyView.
Field‐free spin‐orbit torque domain‐wall synapses integrated with stochastic MTJ neurons enable compact hardware Boltzmann machines. Leveraging intrinsic stochasticity and multi‐level conductance, the system achieves efficient probabilistic learning with high accuracy, demonstrating a scalable spintronic platform for energy‐efficient edge AI.
Aijaz H. Lone, Meng Tang, Camelia Florica, Bin He, Jingkai Xu, Selma Amara, Georgian Melinte, Xixiang Zhang, Gianluca Setti   +8 more
wiley   +1 more source