Results 11 to 20 of about 136,944 (187)

Discovery of Oxyacanthine Dihydrochloride Monohydrate Polymorphs from Obfuscated Samples by Microcrystal Electron Diffraction. [PDF]

ChemMedChem
The practical application of microcrystal electron diffraction is demonstrated to identify two polymorphic crystal structures of oxyacanthine dihydrochloride monohydrate from obfuscated samples that had been mislabeled as "berbamine dihydrochloride".
Lin J, Paz O, Unge J, Gonen T.
europepmc   +2 more sources

Standards for MicroED [PDF]

Struct Dyn
With an increasing number of refined MicroED structures available to the community, lessons can be learned of their profiles and quality, as well as of best practices.As the electron diffraction technique MicroED gains momentum and is increasingly embraced by researchers in both academia and industry, we have the opportunity to familiarize ourselves ...
Unge J, Nannenga B, Oliver A, Gonen T.
europepmc   +3 more sources

Minimally Invasive Intraoperative Laser Vibrometry (MIVIB)-A Peroperative Method to Measure Fixation of the Ossicular Chain. [PDF]

Laryngoscope Investig Otolaryngol
An objective assessment of the ossicular chain with laser vibrometry would likely improve the result of ossiculoplasty. MIVIB provides an objective assessment of the ossicular chain to identify specific fixations and therefore assist the surgeon in improving surgical outcomes. ABSTRACT Background Conductive hearing loss requires the surgeon to evaluate
Wales J, Muyshondt PGG, Silvola J, Livens P, Gladiné K, Dirckx JJJ, von Unge M.   +6 more
europepmc   +2 more sources

Clinical Trial: Dose-Finding Study of Linaprazan Glurate, A Novel Potassium-Competitive Acid Blocker, Versus Lansoprazole for the Treatment of Erosive Oesophagitis. [PDF]

Aliment Pharmacol Ther
Linaprazan glurate achieved a 4‐week healing rate of 71.1% in the intention‐to‐treat (ITT) analysis and 80.9% in the per protocol set (PPS) analysis. In comparison, lansoprazole achieved healing rates of 60.6% (ITT) and 59.1% (PPS). ABSTRACT Background Linaprazan glurate, a potassium‐competitive acid blocker, is in development for the treatment of ...
Sharma P, Vaezi M, Unge P, Andersson K, Larsson K, Popadiyn I, Rosenholm M, Rosztóczy A, Yektaei E, Armstrong D.   +9 more
europepmc   +2 more sources

Distinct MAIT cell phenotypes associated with sepsis clinical outcome in emergency department patients. [PDF]

Clin Transl Immunology
In this study, mucosal‐associated invariant T (MAIT) cell characteristics were evaluated in blood from patients who triggered a clinical sepsis alert at the emergency department. High‐dimensional phenotyping revealed distinct MAIT cell activation profiles between sepsis and non‐sepsis groups. In sepsis patients, hierarchical clustering identified three
Emgård J, Filipovic I, Unge C, Palma Medina LM, Parke Å, Bergsten H, Moll K, Dzidic M, Alpkvist H, Fang H, Özenci V, Björkström NK, Svensson M, Sandberg JK, Strålin K, Norrby-Teglund A.   +15 more
europepmc   +2 more sources

An Updated Structure of Oxybutynin Hydrochloride. [PDF]

Adv Sci (Weinh)
Oxybutynin (Ditropan) is a widely prescribed muscarinic antagonist for treating the overactive bladder. Previous powder X‐ray diffraction (PXRD) structures has problems like inconsistency with 2D chemical structure and X‐ray‐induced photoreduction. Here microcrystal electron diffraction (MicroED) is used to unveil a definitive and improved 3D structure
Lin J, Bu G, Unge J, Gonen T.
europepmc   +2 more sources

Unlocking Enhanced Efficacy of Aminoglycoside Antibiotics Against Pseudomonas aeruginosa. [PDF]

Microb Biotechnol
This opinion article reviews the use and challenges of aminoglycosides on the Gram‐negative pathogen Pseudomonas aeruginosa and highlights recent discoveries of adjuvants and/or other compounds that potentiate the activity of these antibiotics. ABSTRACT Infectious diseases continue to be a global health burden.
Tawiah PO, Sultana S, Dahl JU.
europepmc   +2 more sources

Structure of L-arginine and detection of trace DL-arginine by 3D ED. [PDF]

Acta Crystallogr C Struct Chem
The single‐crystal structures of l‐arginine and a trace impurity of racemic dl‐arginine present in commercially sourced arginine have been determined using 3D ED. The single‐crystal structure for l‐arginine was previously unavailable.3D electron crystallography has emerged as a method with great potential for the structure determination of small ...
Khakurel KP, Mahmoudi S.
europepmc   +2 more sources

Environmental and Genetic Influences on Developmental Outcomes Across the Domains of Language, Cognition, Motor Function, and Social Behavior. [PDF]

Eur J Neurosci
We investigated the association between the home environment (HOME) and a polygenic score (PGS) for educational attainment (EA) with multiple developmental domains, both individually and, through principal component analysis (PCA), simultaneously. HOME was significantly associated with all developmental domains and with PC1, which captured most of the ...
Schiavon M, Burton BK, Hemager N, Greve AN, Spang KS, Ellersgaard D, Plessen KJ, Jepsen JRM, Thorup AAE, Werge T, Nordentoft M, Nudel R.   +11 more
europepmc   +2 more sources

Branes at Generalized Conifolds and Toric Geometry [PDF]

, 1999
We use toric geometry to investigate the recently proposed relation between a set of D3 branes at a generalized conifold singularity and type IIA configurations of D4 branes stretched between a number of relatively rotated NS5 branes.
von Unge, Rikard
core   +2 more sources