Results 111 to 120 of about 1,850,577 (245)

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

El Servicio de Acción Exterior de la Unión Europea [PDF]

, 2008
La representación internacional de la Unión Europea (UE) bajo el Derecho originario vigente y la práctica hasta ahora desarrollada tanto por la Unión como por la Comunidad Europea es fiel reflejo de la complejidad institucional y de la integración ...
Fernandez Sola, Natividad
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TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Resolución del Parlamento Europeo, de 12 de mayo de 2011, sobre "Liberar el potencial de las industrias culturales y creativas" (2010/2156(INI)) [PDF]

, 2012
Parlamento EuropeoDentro del epígrafe "Hacia una mejor difusión y circulación de las obras en la era digital", en los puntos 44 y 45, trata sobre las bibliotecas y, concretamente, sobre la importancia de la adaptación digital de las ...
Consejo de la Unión Europea
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Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Más allá de las becas: Percepciones de inclusión y apoyo académico en participantes universitarios peruanos

Actualidades Investigativas en Educación
La existencia de políticas de inclusión y apoyo académico en las universidades respalda la idea de una educación disponible e igualitaria para todo el estudiantado, sin embargo existen barreras y facilitadores que influyen en la experiencia académica y ...
Willian Huamanttupa Mar, Elsa Flores Hilario, Frida Huayto Cupe, Faustino Ronal Ccotaccallapa Choque, Danitza Elfi Montalvo Apolin   +4 more
doaj   +1 more source

Jurisprudencia ambiental en la Unión Europea [PDF]

, 2015
Jurisprudencia ambiental en la Unión ...
Cardesa Salzmann, Antonio
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Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Archivo Digital España Unión Europea (Sedas) [PDF]

, 2015
Comunicación presentada al XIV Workshop Rebiun de Poyectos Digitales / VI Jornadas OS-Repositorios (Córdoba, 11-13 de marzo de 2015)Proponemos una comunicación sobre ?Archivo-Digital España Unión Europea?
Aleixandre Baeza, Elvira, García Muñoz, Teresa   +1 more
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