Results 131 to 140 of about 798,477 (197)

Long-term clinical and radiological outcomes following non-union surgery: ongoing remodeling and improvement in clinical findings after five years. [PDF]

J Orthop Surg Res
Böpple JC, Skeik A, Tanner M, Ferbert T, Bewersdorf TN, Schamberger C, Schmidmaier G, Findeisen S.   +7 more
europepmc   +1 more source

Interferon beta drives therapy resistance in a patient‐derived model of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Interferon type 1 (IFN‐1) production and signaling is associated with the acquisition of therapy resistance, following chronic DNA damage, via Interferon‐related DNA damage resistance signature (IRDS) gene expression. An alternative, DNA damage‐independent role of sustained IFN‐1 mediated resistance was identified and characterized by the emergence of ...
Ashlyn Conant, Tise Suzuki, Kiera McGivney, V. S. S. Abhinav Ayyadevara, Sharon Asariah, Jay Deng, Ethan Nyein, Jacqueline Coats, Gary Yu, Yevgeniya J. Ioffe, Christian Hurtz, Juli J. Unternaehrer   +11 more
wiley   +1 more source

Retraction Note: Heart transplantation: comparing the impact of modified heart preservation with conventional methods. [PDF]

Sci Rep
Shang X, Zhang C, Wang Y, Liu M, Zhong Y, Dong N.   +5 more
europepmc   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Correction: Phenotypic and transcriptomic characterization of two newly described Mycobacterium species within the <i>Mycobacterium gordonae</i> complex. [PDF]

Front Microbiol
Gan T, Mei Y, Jiang H, Zhang W, Shi Y, Wang H.   +5 more
europepmc   +1 more source

PANoptosis in the pathogenesis of myelodysplastic syndromes

Molecular Oncology, EarlyView.
PANoptosis, a combination of three types of programmed cell death, is mediated by a large protein complex called a PANoptosome. In healthy bone marrow hematopoietic cells, PANoptosis is restricted by inhibitory signaling. In MDS, bone marrow cells become sensitive to the PANoptotic stimuli due to the aberrant inactivation of inhibitory signaling or ...
Rohit Thalla, Jyoti Lamichhane, Cameron Lewis, Peter Breslin, Jiwang Zhang   +4 more
wiley   +1 more source

Free Fibula Flap Arthrodesis After En Bloc Resection of Distal Radius Giant Cell Tumors: Functional and Oncologic Outcomes From a Single-institution Experience. [PDF]

Plast Reconstr Surg Glob Open
Abdel Al S, Abu Shokor M, Daradkeh B, Abualhaj S, Alayyan O, Makahleh M, Al Salhi I, Alattar MA, Erjan A, Asha W, Yaser S.   +10 more
europepmc   +1 more source

Spatial biology in cancer epigenetics

Molecular Oncology, EarlyView.
Spatial epigenomics combines molecular profiling with tissue architecture to reveal how gene regulation is organized within intact tissues. In cancer, these technologies uncover the mechanisms driving tumor heterogeneity and microenvironmental interactions, opening new opportunities for biomarker discovery and precision medicine.
Eva Crespo‐García, Manel Esteller
wiley   +1 more source

Functional Outcome and Complications of Wide Excision of the Distal End of Radius and Reconstruction with Ulnar Transposition in Campanacci Grade III Giant Cell Tumor: A Longitudinal Study of 14 Cases in South India. [PDF]

J Orthop Case Rep
Krishna SS, Davis D, John KA, Puthoor DK.   +3 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source