Results 41 to 50 of about 795,738 (197)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Emotional intelligence as protective factor in adolescents with suicidal ideation

Duazary, 2018
The objective of the present study is to determine the effectiveness of an intervention program to develop emotional intelligence in a risk group. The methodology involves a quasi experimental design, with intact group, the same that was submitted to an ...
Oscar Javier Mamani-Benito, Magaly Alejandra Brousett-Minaya, Duumy Neyma Ccori-Zúñiga, Karen Shirley Villasante-Idme   +3 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Lord Acton, el victoriano confederado: en defensa de la primitiva Unión y los derechos de los estados

Araucaria
Lord Acton se mostró partidario de la causa Confederada. Lo hizo guiado por su sentido de la Historia y del poder: los ideales tienen una potencia transformadora y los estados del Sur proclamaron la secesión movidos por la reivindicación de los principios originales de la Revolución norteamericana frente a la tiranía de la mayoría. Acton no entra
openaire   +5 more sources

Francisco Suárez y los efectos del Sacramento Eucarístico

Estudios Eclesiásticos, 1958
Francisco Suárez se inició prematuramente en la formación cristiana. Entró con diez años al seminario en Granada. Allí se confirma el inicio de su devoción eucarística.
José Sagüés Azcona
doaj  

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

FEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz, Mihály Mérey, Rebeka Vásárhelyi, Ramóna Pék, Victor Imburchia, László Henn, Adrián Kószó, Nicholas D. Lakin, Ivan Ahel, Sébastien Huet, Ágnes Czibula, Gyula Timinszky   +11 more
wiley   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

FEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

¿Optimismo o pesimismo por los resultados del movimiento unionista?

Estudios Eclesiásticos, 1959
Algunas autoridades de las diferentes Iglesias cristianas se reunieron en Ginebra en octubre de 1955 con el anhelo común de buscar todo lo que nos une. La división de los cristianos supone uno de los mayores obstáculos para los que no creen. En el último
Ignacio Riudor
doaj