Results 51 to 60 of about 802,813 (248)

¿Optimismo o pesimismo por los resultados del movimiento unionista?

Estudios Eclesiásticos, 1959
Algunas autoridades de las diferentes Iglesias cristianas se reunieron en Ginebra en octubre de 1955 con el anhelo común de buscar todo lo que nos une. La división de los cristianos supone uno de los mayores obstáculos para los que no creen. En el último
Ignacio Riudor
doaj  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Inteligencia emocional y procrastinación académica en estudiantes universitarios en Perú

Ciencias Psicológicas
El objetivo de este estudio fue analizar la relación entre la Inteligencia Emocional (IE) y la Procrastinación Académica (PA) en estudiantes universitarios y generar un modelo predictivo. Este estudio tiene un enfoque cuantitativo y de diseño predictivo
Samuel Chavez-Fernandez, Yeniffer M. Haro-Rodriguez, Lucero G. Machaca-Calcina, Cristian E. Adriano Rengifo   +3 more
doaj   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Simón Bolívar y José Martí: analogía en un pensamiento por la Unión Americana

Política Internacional, 2019
Revelar la ideología del imperativo de la unión para alcanzar la verdadera emancipación, garantizar mediante ella la protección y amparo de Las Antillas y Latinoamérica y enfrentar el ascendente interés norteamericano de instalarse y posesionarse de ...
Aíxa Cristina Kindelán Larrea
doaj  

Fusiones / Adquisiciones y Acuerdos de Cooperación en la Unión Europea durante el periodo 2000-2007

Revista Galega de Economía, 2014
La realización de fusiones/adquisiciones y de acuerdos de cooperación dentro del marco europeo ha sido creciente a lo largo del siglo pasado. Sin embargo, la llegada del nuevo siglo nos muestra algunos cambios en las tendencias. El objetivo de este trabajo es analizar de forma descriptiva las características y evolución de las fusiones ...
openaire   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source