Results 91 to 100 of about 231,559 (266)
Molecular Oncology, EarlyView.Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute +4 more
wiley +1 more source
Minimal Pati-Salam Model from String Theory Unification
, 2007 We provide what we believe is the minimal three family ${\cal N} = 1$ SUSY and conformal Pati-Salam Model from type IIB superstring theory. This $Z_3$ orbifolded AdS$\otimes S^5$ model has long lived protons and has potential phenomenological ...
James B. Dent +2 more
core +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
Quantum Gravity: Unification of Principles and Interactions, and Promises of Spectral Geometry
Symmetry, Integrability and Geometry: Methods and Applications, 2007 Quantum gravity was born as that branch of modern theoretical physics that tries to unify its guiding principles, i.e., quantum mechanics and general relativity.
Bernhelm Booß-Bavnbek +2 more
doaj
What is Information? A multidimensional concern
tripleC: Communication, Capitalism & Critique, 2010 Looking for an answer to the posed question, we will first go through a brief historical enquiry aiming at exploring the development of the uses given to the Latin word “information” from its Greek roots until its scientific formalisation in hands of the
José María Díaz Nafría
doaj +1 more source
Unification and Anti-unification modulo Equational Theories
EPiC Series in Computing, 2018 Automated reasoning modulo an equational theory E is a fundamental technique in many applications. In this talk, we would present a narrowing-based equational unification algorithm for theories satisfying the finite variant property.
openaire +2 more sources
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Cold Dark Matter and b --> s gamma in the Horava-Witten Theory
, 2001 The minimal supersymmetric standard model with complete, partial or no Yukawa unification and radiative electroweak breaking with boundary conditions from the Horava-Witten theory is considered.
Adel +46 more
core +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
Toward a Unified Grammar of Reference
Zeitschrift für Sprachwissenschaft, 2005 The unification of traditionally distinct and apparently unrelated objects of inquiry under common more abstract principles is one of the most welcome results of empirical science. This article proposes to draw together some insights of Longobardi (1994,
Longobardi Giuseppe
doaj +1 more source