Results 81 to 90 of about 231,559 (266)
Molecular Oncology, EarlyView.This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns +10 more
wiley +1 more source
331 models and grand unification: From minimal SU(5) to minimal SU(6)
Physics Letters B, 2016 We consider the possibility of grand unification of the SU(3)c⊗SU(3)L⊗U(1)X model in an SU(6) gauge unification group. Two possibilities arise. Unlike other conventional grand unified theories, in SU(6) one can embed the 331 model as a subgroup such that
Frank F. Deppisch +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson +9 more
wiley +1 more source
RIPK4 function interferes with melanoma cell adhesion and metastasis
Molecular Oncology, EarlyView.RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang +12 more
wiley +1 more source
Why Pursue Unification? A Social-Epistemological Puzzle
Theoria, 2015 Many have argued that unified theories ought to be pursued wherever possible. We deny this on the basis of social-epistemological and game-theoretic considerations.
Randall Harp, Kareem Khalifa
doaj +1 more source
Molecular Oncology, EarlyView.Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla +9 more
wiley +1 more source
Supercondunting Field Theory (the Unification Theory)
, 2023 Unification theory with no extra dimensions. The first part unifies the strong nuclear force with the gravitational force in a mathematical way, the second part unifies the nuclear force with the quantum vacuum in a hypothetical structure.
openaire +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
, 2011 We show how gauge coupling unification is successfully implemented through non-supersymmetric grand unified theory, $SO(10)\times G_f (~G_f=S_4, SO(3)_f, SU(3)_f)$, using low-scale flavor symmetric model of the type $SU(2)_L\times U(1)_Y$ $ \times SU(3 ...
Bora, Kalpana +2 more
core +1 more source