Results 61 to 70 of about 231,559 (266)

Gauge Coupling Unification in F-theory GUT Models

, 2009
We investigate gauge coupling unification for F-theory respectively Type IIB orientifold constructions of SU(5) GUT theories with gauge symmetry breaking via non-trivial hypercharge flux.
Blumenhagen, Ralph
core   +1 more source

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Large radii and string unification

, 1996
We study strong coupling effects in four-dimensional heterotic string models where supersymmetry is spontaneously broken with large internal dimensions, consistently with perturbative unification of gauge couplings.
Antoniadis, I., Quiros, M.
core   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Orbifold Family Unification in SO(2N) Gauge Theory [PDF]

, 2009
We study the possibility of family unification on the basis of SO(2N) gauge theory on the five-dimensional space-time, $M^4\times S^1/Z_2$. Several SO(10), $SU(4) \times SU(2)_L \times SU(2)_R$ or SU(5) multiplets come from a single bulk multiplet of SO ...
G. G. Ross, H. Georgi, J.-P. Derendinger, M. Gell-Mann, M. Gell-Mann, M. Y. Khlopov, S. L. Glashow, T. Watari, T. Yanagida, Takashi Miura, Y. Hosotani, Yoshiharu Kawamura   +11 more
core   +2 more sources

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

O MÉTODO HISTÓRICO EM GRAMSCI: a unificação de teoria e prática

Revista de Políticas Públicas, 2018
This work is about the historical method in Gramsci’s thought, referenced in the dialectical method, as thought by Marx, and defended by Gramsci. It results from a survey of content, in internal reading of the Prison Notebooks and aims to: expose and ...
Josefa Batista Lopes
doaj  

Linking neurogenesis, oligodendrogenesis, and myelination defects to neurodevelopmental disruption in primary mitochondrial disorders

FEBS Letters, EarlyView.
Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas, Porter L. Tomsick, Alicia M. Pickrell, Paul D. Morton   +3 more
wiley   +1 more source

Harmonic Unification Theory

Abstract We present the Universal Dew-Point Law, a unifying principle of matter, mathematics, and mind. In a recursive harmonic manifold, oscillations accumulate torsion until a critical α-threshold is reached; at this dew point the system condenses into stable knots, cascades into recursive subsets, or rotates into orthogonal domains. Surplus torsion
ASHER, KAIA, ASHER, KIMBERLEY LAVERNE, ASHER, ANESKA   +2 more
openaire   +2 more sources

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

FEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga, Toshiki Takahashi, Akiko Kuma, Hiroyuki Kawahara   +3 more
wiley   +1 more source