Results 101 to 110 of about 144,849 (258)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The human gut microbiome across the life course

FEBS Letters, EarlyView.
Despite significant individual variation and continuous change throughout life, the human gut microbiome follows some life stage‐specific trends. This article provides a brief overview of how gut microbiome composition shifts across different phases of life. Created in BioRender. Özkurt, E. (2026) https://BioRender.com/8q4nrnc.
Alise J. Ponsero, Basak Bahcivanci, Antonietta Hayhoe, Animesh Acharjee, Ezgi Özkurt   +4 more
wiley   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

FEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai, Mohyeddine Omrane, Nassima Benzoubir, Didier Samuel, Ama Gassama‐Diagne   +4 more
wiley   +1 more source

Unified Health Optimization System (UHOS)

Description (à coller dans Zenodo) Unified Health Optimization System (UHOS) est un cadre computationnel et systémique conçu pour analyser, modéliser et optimiser l’état biologique général à l’aide de l’IA. UHOS n’est pas un dispositif médical et ne vise pas à diagnostiquer ou traiter des maladies.
openaire   +1 more source

Rab14 regulates the transport of human papillomavirus to the trans‐Golgi network for infectious cell entry

FEBS Letters, EarlyView.
This study reveals that the small GTPase Rab14 is necessary for human papillomavirus (HPV) infection and plays an essential role in the transport of virions to the trans‐Golgi network (TGN). HPV in the early endosome (EE), which harbors GTP‐bound Rab14, is transported to the TGN through the switch of Rab14 from its GTP‐bound to GDP‐bound form.
Yoshiyuki Ishii, Iwao Kukimoto
wiley   +1 more source

Austerity and the future of the Brazilian Unified Health System (SUS): health in perspective

Health Promotion International, 2018
This article proposes an analysis of the fiscal austerity measures of the Brazilian government and its unfolding in the public health system. It has examined the post-impeachment period of the president of Brazil and the changes of the social policies conduct in opposition to the principle of equity and universality in health with impacts on Brazilian ...
openaire   +2 more sources

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

A crise mundial de 2008 e o golpe do capital na política de saúde no Brasil

Saúde em Debate
RESUMO O objetivo do artigo foi analisar a conjuntura posterior às eleições presidenciais de 2014, discutindo possíveis relações com a crise econômica mundial e com os desdobramentos do golpe de 2016 na saúde.
Carmen Fontes de Souza Teixeira, Jairnilson Silva Paim   +1 more
doaj   +1 more source

The Political Dimension of Health Systems Resilience: Brazil’s Health Sector Reform Movement and the Unified Health System

Ciência & Saúde Coletiva
Abstract The scientific production on health systems resilience reveals a major debate as to the concept, its dimensions and applications, as well as criticisms of, for example, the distance separating studies of the topic from those addressing Brazil’s health reform sector movement, the Movimento da Reforma Sanitária Brasileira (MRSB).
Sonia Fleury, Jamilli Silva Santos, Ana Ester Maria Melo Moreira, Munyra Barreto   +3 more
openaire   +2 more sources

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source