Results 91 to 100 of about 66,253 (289)

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Transient Stability Enhancement Using Adaptive Neuro-Fuzzy-Based Unified Power Flow Controller

Scientific African
A power system is a complex, non-linear, and dynamic system, with operating parameters that change over time. Because of the complexity of big load lines and faults, high-voltage transmission power systems are usually vulnerable to transient instability ...
Yechale Amogne Alemu, Belachew Bantyirga Gessesse, Molla Addisu Mossie   +2 more
doaj   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Advanced Capacity-Expansion-Type Unified Power Flow Controller Based on Single-Core Phase-Shifting Transformer

Energies
In light of the growing complexity and demand in modern power systems, there is an increasing need for reliable, efficient, and flexible power flow control mechanisms.
Ningyu Zhang, Huarui Li, Jicheng Fang, Chongze Bi, Xiaokuan Jin, Jianhua Wang   +5 more
doaj   +1 more source

The effect of data preprocessing on the performance of artificial neural networks techniques for classification problems [PDF]

, 2012
The artificial neural network (ANN) has recently been applied in many areas, such as medical, biology, financial, economy, engineering and so on. It is known as an excellent classifier of nonlinear input and output numerical data.
Atomi, Walid Hasen
core  

Systemic dysregulation of apolipoproteins in amyotrophic lateral sclerosis serum

FEBS Open Bio, EarlyView.
Amyotrophic lateral sclerosis (ALS) is a fatal disease that damages motor neurons. This study found that people with ALS show significant changes in blood fats and the proteins that carry them. Several apolipoproteins were higher, lipid balances were altered, and normal protein–lipid relationships were disrupted.
Finula I. Isik, Russell Pickford, Hannah C. Timmins, Olivier Piguet, Glenda M. Halliday, Matthew C. Kiernan, Woojin Scott Kim   +6 more
wiley   +1 more source

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Unified power flow controllers in smart power systems: models, methods, and future research

IET Smart Grid, 2018
Power flow control has become increasingly important in recent years in the area of smart power systems that have to integrate increased shares of variable renewable energy sources.
Pavlos S. Georgilakis, Nikos D. Hatziargyriou   +1 more
doaj   +1 more source

Performance Implications of NoCs on 3D-Stacked Memories: Insights from the Hybrid Memory Cube

, 2018
Memories that exploit three-dimensional (3D)-stacking technology, which integrate memory and logic dies in a single stack, are becoming popular. These memories, such as Hybrid Memory Cube (HMC), utilize a network-on-chip (NoC) design for connecting their
Asgari, Bahar, Garg, Kartikay, Hadidi, Ramyad, Kim, Hyesoon, Krishna, Tushar, Mudassar, Burhan Ahmad, Young, Jeffrey   +6 more
core   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source