Results 71 to 80 of about 66,253 (289)

Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma

Molecular Oncology, EarlyView.
Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken, Andrea Abel Gutierrez, Imke van Rossum, Cornelia G. Spruijt, Michiel Vermeulen, Guido van Mierlo, Blanca Scheijen, Annemiek B. van Spriel   +7 more
wiley   +1 more source

Power system damping enhancement using unified power flow controller (UPFC)

Electrical Engineering in Japan, 1999
The Unified Power Flow Controller (UPFC) can inject voltage with controllable magnitude and phase angle in series with a transmission line. It can also generate or absorb controllable reactive power. UPFC is expected to be able to damp power system oscillations more effectively than power electronics devices such as SVG and TCSC.
Hirotoshi Kohno, Tatsuhito Nakajima, Akihiko Yokoyama   +2 more
openaire   +2 more sources

Infrared laser sampling of low volumes combined with shotgun lipidomics reveals lipid markers in palatine tonsil carcinoma

Molecular Oncology, EarlyView.
Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff, Manuela Moritz, Dennis Eggert, Anna Worthmann, Joerg Heeren, Henrike Zech, Till S. Clauditz, Waldemar Wilczak, Hartmut Schlüter, Christian S. Betz, Arne Böttcher, Jan Hahn   +11 more
wiley   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Peningkatan Available Transfer Capability Mengggunakan Unified Power Flow Controller

Jurnal Teknik ITS, 2012
Available Transfer Capability (ATC) adalah kemampuan transfer yang masih mungkin bisa dilakukan pada sistem tenaga listrik. Pemasangan perangkat FACTS, yaitu Unified Power Flow Controller (UPFC) dilakukan untuk meningkatkan nilai ATC.
Adyatmoko Wirananto, Adi Soeprijanto, Rony Seto Wibowo   +2 more
doaj  

Optimal robust stabilizer design based on UPFC for interconnected power systems considering time delay

Archives of Electrical Engineering, 2017
A robust auxiliary wide area damping controller is proposed for a unified power flow controller (UPFC). The mixed H2 / H∞ problem with regional pole placement, resolved by linear matrix inequality (LMI), is applied for controller design.
Koofigar Hamid Reza, Isazadeh Ghader
doaj   +1 more source

Performance Studies of Static Synchronous Compensator and Static Synchronous Series Compensator Modes for Convertible Static Compensator [PDF]

, 2005
This thesis presents an overview of the emerging Flexible AC Transmission System (FACTS) and Convertible Static Compensator (CSC) technologies. CSC, the flexible multifunctional compensator is an innovation fi-om FACTS technology.
Abd Halim, Wahidah
core  

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Subsynchronous resonance and its mitigation for power system with unified power flow controller

Journal of Modern Power Systems and Clean Energy, 2017
Control strategy of unified power flow controller (UPFC) utilizing dq decoupling control is deduced in this paper, which can closely follow the control orders of the active and reactive power.
Xinyao ZHU, Meng JIN, Xiangping KONG, Jingbo ZHAO, Jiankun LIU, Qian ZHOU   +5 more
doaj   +1 more source