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A new convenient methodology based on dihydropyridine derivative for selective fluorimetric analysis of baclofen: Application to spiked urine and content uniformity evaluation

Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy, 2021
Baclofen belongs to skeletal muscle relaxant and is used for the treatment of muscle spasticity that originated from multiple sclerosis or a spinal cord injury and other cases as hiccups. In the current analytical study, a new, convenient and selective fluorimetric method for baclofen analysis has been developed and validated.
Ahmed A, Abu-Hassan   +2 more
openaire   +2 more sources

Seismic fragility assessment framework for highway bridges based on an improved uniform design-response surface model methodology

Bulletin of Earthquake Engineering, 2020
This paper proposes an improved uniform design (UD)-response surface model (RSM) method to reduce the impacts of sample correlation among small sample data caused by UD method and variable substitution process in the traditional UD-RSM method. The proposed B-spline-PLS-UD-RSM method, which is a systematic approach that combines nonlinear B-spline ...
Huihui Li   +3 more
openaire   +1 more source

A Science and Risk-Based Pragmatic Methodology for Blend and Content Uniformity Assessment

AAPS PharmSciTech, 2017
This paper describes a pragmatic approach that can be applied in assessing powder blend and unit dosage uniformity of solid dose products at Process Design, Process Performance Qualification, and Continued/Ongoing Process Verification stages of the Process Validation lifecycle.
Naheed, Sayeed-Desta   +3 more
openaire   +2 more sources

Optimization of the coupling parameters and mixing uniformity of multiple organic hydraulic mixtures based on the discrete element method and response surface methodology

Advanced Powder Technology, 2020
Abstract To address the mixing uniformity of multiple organic hydraulic (MOH) mixtures in a continuous mixer, three types of mixing parameters and their coupling effects were studied by the discrete element method (DEM) and response surface methodology.
Lingying Zhao   +5 more
openaire   +1 more source

Numerical simulation and process optimization of an aluminum holding furnace based on response surface methodology and uniform design

Energy, 2014
Abstract It is indispensable for strengthening smelting process and controlling fine to understand metallurgical behaviors and mechanism of production process of aluminum holding furnaces. A CFD (computational fluid dynamics) compressive process model was developed and integrated with energy distribution regime using user subroutines based on FLUENT ...
Ji-min Wang, Shen Lan, Wen-ke Li
openaire   +1 more source

Analysis Methodology of Uniformity for a-Si Based Triple-Junction Thin Film Solar Module by Circuit Model Parameters

2014
Analysis methodology of the uniformity on a-Si based triple-junction thin film solar module for power station or building integrated photovoltaic was developed by using circuit model parameters. For this study, a-Si based triple-junction thin film solar module with a size of 5G, 1300Х1100[mm], was fabricated and cut to a size of 100x100[mm].
Min, Y.   +7 more
openaire   +1 more source

Driving cycle construction methodology based on Markov process and uniform distribution

2016 35th Chinese Control Conference (CCC), 2016
This paper proposes a methodology of constructing driving cycle by Markov process and uniform distribution. On the basis of micro-trip method, the kinematic sequences are divided by acceleration into more micro-segments, which are then classified into six categories by their respective mean velocity.
openaire   +1 more source

Examination of fluorocarbon-based plasmas used in the selective and uniform etching of silicon dioxide by response-surface methodology: Effects of helium addition

Journal of Vacuum Science & Technology B: Microelectronics Processing and Phenomena, 1989
The process parameter space for fluorocarbon plasmas (C2F6/CHF3 and CF4/CHF3, with and without He) which are used to etch SiO2 has been examined with a Lam Research Autoetch 580 parallel plate, single-wafer etching system by response-surface methodology.
Paul E. Riley   +2 more
openaire   +1 more source

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