Results 91 to 100 of about 1,930,208 (286)

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Bayesian estimation of genotypic and phenotypic correlations from crop variety trials

open access: yesCrop Breeding and Applied Biotechnology, 2016
Genotypic and phenotypic correlations are necessary for constructing indirect selection indices. Bayesian analysis, therefore, was applied to obtain posterior distributions of the correlations, and the estimates were compared with those under a ...
Siraj Osman Omer   +3 more
doaj  

Bayesian inference is facilitated by modular neural networks with different time scales.

open access: yesPLoS Computational Biology
Various animals, including humans, have been suggested to perform Bayesian inferences to handle noisy, time-varying external information. In performing Bayesian inference by the brain, the prior distribution must be acquired and represented by sampling ...
Kohei Ichikawa, Kunihiko Kaneko
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

RCDi: Robust Causal Direction Inference Using INUS-Inspired Asymmetry with the Solomonoff Prior

open access: yesMathematics
Investigating causal interactions between entities is a crucial task across various scientific domains. The traditional causal discovery methods often assume a predetermined causal direction, which is problematic when prior knowledge is insufficient ...
Ling Zhao   +4 more
doaj   +1 more source

Prior Elicitation in Multiple Change-point Models [PDF]

open access: yes
This paper discusses Bayesian inference in change-point models. The main existing approaches either attempt to be noninformative by using a Uniform prior over change-points or use an informative hierarchical prior.
Gary Koop, Simon M. Potter
core  

Pose for Action - Action for Pose

open access: yes, 2017
In this work we propose to utilize information about human actions to improve pose estimation in monocular videos. To this end, we present a pictorial structure model that exploits high-level information about activities to incorporate higher-order part ...
Gall, Juergen   +2 more
core   +1 more source

Multi‐omics and low‐input proteomics profiling reveals dynamic regulation driving pluripotency initiation in early mouse embryos

open access: yesFEBS Open Bio, EarlyView.
Mouse pre‐implantation development involves a transition from totipotency to pluripotency. Integrating transcriptomics, epigenetic profiling, low‐input proteomics and functional assays, we show that eight‐cell embryos retain residual totipotency features, whereas cytoskeletal remodeling regulated by the ubiquitin‐proteasome system drives progression ...
Wanqiong Li   +8 more
wiley   +1 more source

Uniform Priors for Data-Efficient Learning

open access: yes2022 IEEE/CVF Conference on Computer Vision and Pattern Recognition Workshops (CVPRW), 2022
Sinha, S.   +6 more
openaire   +3 more sources

C2α‐carbanion‐protonating glutamate discloses tradeoffs between substrate accommodation and reaction rate in actinobacterial 2‐hydroxyacyl‐CoA lyase

open access: yesFEBS Open Bio, EarlyView.
Enzymes of the 2‐hydroxyacyl‐CoA lyase group catalyze the condensation of formyl‐CoA with aldehydes or ketones. Thus, by structural adaptation of active sites, practically any pharmaceutically and industrially important 2‐hydroxyacid could be biotechnologically synthesized. Combining crystal structure analysis, active site mutations and kinetic assays,
Michael Zahn   +4 more
wiley   +1 more source

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