Results 51 to 60 of about 1,930,208 (286)
Deriving Proper Uniform Priors for Regression Coefficients, Parts I, II, and III [PDF]
Entropy, 2017 It is a relatively well-known fact that in problems of Bayesian model selection, improper priors should, in general, be avoided. In this paper we will derive and discuss a collection of four proper uniform priors which lie on an ascending scale of informativeness.
H.R. Erp, Ronald. Linger, Pieter Gelder
openaire +4 more sources
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
Improved high power/high frequency inductor [PDF]
, 1990 A toroidal core is mounted on an alignment disc having uniformly distributed circumferential notches or holes therein. Wire is then wound about the toroidal core in a uniform pattern defined by the notches or holes.
Mclyman, W. T.
core +1 more source
Free Lunch for Optimisation under the Universal Distribution [PDF]
, 2016 Function optimisation is a major challenge in computer science. The No Free Lunch theorems state that if all functions with the same histogram are assumed to be equally probable then no algorithm outperforms any other in expectation. We argue against the
Everitt, Tom +2 more
core +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
PLoS ONE, 2019 The prior probabilities of true outcomes for scientific replication have to be uniform by definition. This is because for replication, a study's observations are regarded as samples taken from the set of possible outcomes of an ideally large continuation
Huw Llewelyn
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
BMC Gastroenterology, 2023 Background In 2014, the national population-based colorectal cancer (CRC) screening program was implemented in the Netherlands. Biennial fecal immunochemical testing (FIT) for hemoglobin (Hb) is used at a cut-off of 47 µg Hb per gram feces.
Emilie C. H. Breekveldt +10 more
doaj +1 more source
Bayesian inference for orbital eccentricities
, 2012 Highest posterior density intervals (HPDI's) are derived for the true eccentricities of spectroscopic binaries with measured values e ~ 0. These yield upper limits when e is below the detection threshold e_th and seamlessly transform to upper and lower ...
Eastman +11 more
core +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source