Results 111 to 120 of about 1,391,367 (292)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

On the uniform exponential stability of linear skew-product semiflows

Journal of Function Spaces and Applications, 2006
The problem of uniform exponential stability of linear skew-product semiflows on locally compact metric space with Banach fibers, is discussed. It is established a connection between the uniform exponential stability of linear skewproduct semiflows and ...
Ciprian Preda
doaj   +1 more source

Uniform trehalose nanogels for glucagon stabilization

RSC Applied Polymers
Uniform trehalose nanogels improve stability and solubility of glucagon in aqueous solution, particularly useful for long term storage at cold temperatures. Additionally, the glucagon nanogels were nontoxic, nonhemolytic, and efficacious in vitro.
Ellie G. Puente, Rajalakshmi P. Sivasankaran, Daniele Vinciguerra, Jane Yang, Haillie-Ann C. Lower, Andrea L. Hevener, Heather D. Maynard   +6 more
openaire   +2 more sources

Pharmacological inhibition of the PERK pathway modulates hepatocellular carcinoma growth and immune signaling

FEBS Open Bio, EarlyView.
Pharmacological inhibition of PERK in a DEN‐induced mouse model of liver cancer does not reduce tumor burden but alters cellular stress signaling. Despite blocking PERK activity, downstream stress responses, including CHOP expression, remain active, suggesting compensatory mechanisms within the unfolded protein response that may influence tumor ...
Ada Lerma‐Clavero, Maria Kopsida, Nathalie Arendt, Hans Lennernäs, Markus Sjöblom, Femke Heindryckx   +5 more
wiley   +1 more source

A uniform quantitative stiff stability estimate for BDF schemes [PDF]

Opuscula Mathematica, 2006
The concepts of stability regions, \(A\)- and \(A(\alpha)\)-stability - albeit based on scalar models - turned out to be essential for the identification of implicit methods suitable for the integration of stiff ODEs.
Winfried Auzinger, Wolfgang Herfort
doaj  

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Uniform Stability In Nonlinear Infinite Delay Volterra Integro-differential Equations Using Lyapunov Functionals

Nonautonomous Dynamical Systems, 2016
In [10] the first author used Lyapunov functionals and studied the exponential stability of the zero solution of finite delay Volterra Integro-differential equation. In this paper, we use modified version of the Lyapunov functional that were used in [10]
Raffoul Youssef, Rai Habib
doaj   +1 more source

Uniform Stability of the Hochstadt–Lieberman Problem

Mathematical Notes
In this paper, we prove the uniform stability of the Hochstadt-Lieberman problem, which consists in the recovery of the Sturm-Liouville potential on a half-interval from the spectrum and the known potential on the other half-interval. For this purpose, we reduce the half-inverse problem to the complete one for the unknown potential.
openaire   +3 more sources

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Development of a Prediction Model for Progression Risk in High‐Grade Gliomas Based on Habitat Radiomics and Pathomics

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate the value of constructing models based on habitat radiomics and pathomics for predicting the risk of progression in high‐grade gliomas. Methods This study conducted a retrospective analysis of preoperative magnetic resonance (MR) images and pathological sections from 72 patients diagnosed with high‐grade gliomas (52 ...
Yuchen Zhu, Yuxi Gong, Weilin Xu, Xingjian Sun, Gefei Jiang, Lei Qiu, Kexin Shi, Mengxing Wu, Yinjiao Fei, Jinling Yuan, Jinyan Luo, Yurong Li, Yuandong Cao, Minhong Pan, Shu Zhou   +14 more
wiley   +1 more source