Results 21 to 30 of about 2,992 (250)
Empirical Risk Minimization with Approximations of Probabilistic Grammars [PDF]
, 2010 Probabilistic grammars are generative statistical models that are useful for compositional and sequential structures. We present a framework, reminiscent of structural risk minimization, for empirical risk minimization of the parameters of a fixed ...
Smith, N. A., Cohen, S. B.
core
Empirical Risk Minimization for Probabilistic Grammars: Sample Complexity and Hardness of Learning [PDF]
, 2012 Probabilistic grammars are generative statistical models that are useful for compositional and sequential structures. They are used ubiquitously in computational linguistics.
Noah A. Smith +3 more
core +1 more source
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
‘Guide and Prejudice’— How Argonautes recognize targets across domains of life
FEBS Letters, EarlyView.Argonaute proteins use short nucleic‐acid guides to locate and regulate specific targets across all domains of life. Despite striking diversity—from human gene silencing to bacterial immune defence—all Argonautes share a conserved three‐stage recognition logic: guide‐directed sampling, progressive target pairing with a conformational checkpoint and ...
Jack P. K. Bravo
wiley +1 more source
Strongly uniform bounds from semi-constructive proofs [PDF]
, 2006 In [U. Kohlenbach, Some logical metatheorems with applications in functional analysis, Trans. Amer. Math. Soc. 357 (2005) 89–128], the second author obtained metatheorems for the extraction of effective (uniform) bounds from classical, prima facie non ...
Gerhardy, Philipp, Kohlenbach, Ulrich
core +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Molecular Oncology, EarlyView.Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley +1 more source
Molecular Oncology, EarlyView.Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche +10 more
wiley +1 more source
A New Approach to the Generation of Retractable Plate Structures Based on One-Uniform Tessellations
Journal of Mechanisms and Robotics, 2017 Retractable plate structure (RPS) is a family of structures that is a set of cover plates connected by revolute joints. There exists wide range of possibilities related with these structures in architecture. Configuring the suitable shape of rigid plates that are able to be enclosed without any gaps or overlaps in both closed and open configurations ...
Gazi Gezgin, Aylin, Korkmaz, Koray
openaire +2 more sources