Results 31 to 40 of about 929,622 (227)

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Stochastic homogenization of the laser intensity to improve the irradiation uniformity of capsules directly driven by thousands laser beams [PDF]

, 2011
Illumination uniformity of a spherical capsule directly driven by laser beams has been assessed numerically. Laser facilities characterized by ND = 12, 20, 24, 32, 48 and 60 directions of irradiation with associated a single laser beam or a bundle of NB ...
A.J. Schmitt, B. Canaud, B. Canaud, B. Canaud, B. Canaud, B.J. Le Garrec, E.E. Meshkov, E.I. Moses, G.I. Taylor, J. Giorla, J. Lindl, J. Xiao, J.D. Lindl, J.H. Nuckolls, M. Murakami, M. Murakami, M. Temporal, M. Temporal, M. Temporal, M. Temporal, R. Betti, R.D. Richtmyer, S. Skupsky   +22 more
core   +2 more sources

Uniformization of quasi-uniform spaces [PDF]

Bulletin of the Australian Mathematical Society, 1981
This paper considers the question of when a quasi-uniform space has a compatible uniform structure. Typical of the sufficient conditions provided is the result that a quasi-uniform space whose conjugate topology is compact and R0 is uniformizable.
Raghavan, T. G., Reilly, I. L.
openaire   +1 more source

PARP inhibitors elicit distinct transcriptional programs in homologous recombination competent castration‐resistant prostate cancer

Molecular Oncology, EarlyView.
PARP inhibitors are used to treat a small subset of prostate cancer patients. These studies reveal that PARP1 activity and expression are different between European American and African American prostate cancer tissue samples. Additionally, different PARP inhibitors cause unique and overlapping transcriptional changes, notably, p53 pathway upregulation.
Moriah L. Cunningham, Jasibel Vasquez‐Gonzalez, Samantha M. Barnada, Salome Tchotorlishvili, Latese Jones, Ryan Maguire, Genevieve Lewis, Kinza Rizwan, Jenny Deng, Salma Koachar, Drithi Patel, Hailey Shankle, Tessa Mulders, Namra Ajmal, Charalambos Solomides, Emad S. Alnemri, Teresa F. Alnemri, Ayesha A. Shafi, Leonard G. Gomella, Wm Kevin Kelly, Steven B. McMahon, Matthew J. Schiewer   +21 more
wiley   +1 more source

Discrepancy-based error estimates for Quasi-Monte Carlo. I: General formalism [PDF]

, 1996
We show how information on the uniformity properties of a point set employed in numerical multidimensional integration can be used to improve the error estimate over the usual Monte Carlo one. We introduce a new measure of (non-)uniformity for point sets,
Berblinger, Bratley, Faure, Fox, Graham, Halton, Hlawka, Hoogland, Jiri K. Hoogland, Kleiss, Koksma, Kuipers, Niederreiter, Niederreiter, Niederreiter, Niederreiter, Proinov, Ronald Kleiss, Roth, Sobol, van der Corput, van der Corput, Woźniakowski   +22 more
core   +2 more sources

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

Molecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy, Samuel Hartzler, Paula A. Vargas Carranza, Shyaman Jayasundara, Madison E. Yates, Nimod D. Janson, Bozhi Liu, Annaleigh Benton, Majid Kazemian, Jason A. Hanna   +9 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Reduced vascular leakage correlates with breast carcinoma T regulatory cell infiltration but not with metastatic propensity

Molecular Oncology, EarlyView.
A mouse model for vascular normalization and a human breast cancer cohort were studied to understand the relationship between vascular leakage and tumor immune suppression. For this, endothelial and immune cell RNAseq, staining for vascular function, and immune cell profiling were employed.
Liqun He, Chiara Testini, Neda Hekmati, Altea Bonello, Aglaia Schiza, Emmanuel Nwadozi, Mia Phillipson, Carina Strell, Michael Welsh   +8 more
wiley   +1 more source

VALUE OF INCREASING KERNEL UNIFORMITY [PDF]

Kernel uniformity is an important quality attribute that can now be measured at low cost. This study analyzes the profitability of sorting to increase wheat kernel uniformity.
Brorsen, B. Wade, Lyford, Conrad P., Yoon, Byung-Sam   +2 more
core   +4 more sources

Uniform Sharing [PDF]

, 2019
Collective models have become the go-to framework for intra-household allocations. Available empirical collective models are built for fixed sets of household members and accommodate diversity in household structures with difficulty. Individual-level data on food consumption from Bangladesh provides an opportunity to build a parsimonious model that ...
openaire   +2 more sources