Results 41 to 50 of about 38,300 (288)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

PEDOLOGICAL STUDIES ON SOME SOILS REPRESENTI G DIFFERENT GEOMORPHIC UNITS BASED ON THE MINERAL9GICAL COMPOSITION OF THE F!NE SAND FRACTION. [PDF]

open access: yesJournal of Soil Sciences and Agricultural Engineering, 2003
In order to indicale the origin and uniformity of the soil (orming substratum of some different geomorphological unit of Egypt based on the mii16ralogy of the fine sand (raction (250·(l3~m), sixteen profiles were selected, Tnese profiles represent ...
Faiza Salama,
doaj   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

Enhanced Microwave Heating Uniformity using Reconfigurable Fresnel Zone Plate

open access: yes, 2021
Microwave heating is adapted in diverse industrial applications, but achieving heating uniformity remains elusive. Conventional microwave heating methods are problematic in terms of accurate analysis and the design process is heavily dependent on trial ...
Chang, Suho   +6 more
core  

Side lying during nebulisation can significantly improve apical deposition in healthy adults and adults with mild cystic fibrosis lung disease: a randomised crossover trial

open access: yesBMC Pulmonary Medicine, 2019
Background In people with and without Cystic Fibrosis (CF), does side lying during nebulisation change: the proportion of the dose loaded in the nebuliser that is deposited in the lungs; the uniformity of deposition throughout the lungs; or the apical ...
Ruth L. Dentice   +5 more
doaj   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Quantifying the role of irrigation uniformity on lettuce production and profitability in the Lockyer Valley, Queensland [PDF]

open access: yes, 2010
Water is a major input resource for irrigated agriculture and has a leading role amongst the factors responsible for infield yield variability. The uniformity of irrigation applications is commonly reported to be a key determinant of crop yields and ...
Hussain, Amjed
core  

Psychoanalytic and psychodynamic therapies for depression. The evidence base. [PDF]

open access: yes, 2008
David Taylor, a consultant psychotherapist at the Tavistock & Portman NHS Foundation Trust (120 Belsize Lane, London NW3 5BA, UK. Email: dtaylor@tavi-port.nhs.uk), is the clinical lead of the Tavistock Adult Depression Study (a randomised controlled ...
Taylor, David, David Taylor
core   +1 more source

Is the Three-trial System a Universal Principle? [PDF]

open access: yes, 2023
論文Article日本では三審制が通用するが、中国では通用しない。日本を含む西欧法では事件の処理および法適用の統一性の確保という2 つの要請に応えるために、その審級制度として三審制を採用するが、同じ要請の下であっても現代中国法では四級二審制を採用する。比較法研究を通すと、この相違がそれぞれの社会を支える権利に対する考え方の相違と関連することが明らかになる。The three-trial system works in Japan, but not in China.
御手洗, 大輔   +2 more
core   +1 more source

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