Results 71 to 80 of about 37,696 (254)

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Split Variational Inclusion Problem and Fixed Point Problem for a Class of Multivalued Mappings in CAT(0) Spaces

Mathematics, 2019
The aim of this paper is to introduce a modified viscosity iterative method to approximate a solution of the split variational inclusion problem and fixed point problem for a uniformly continuous multivalued total asymptotically strictly ...
Mujahid Abbas, Yusuf Ibrahim, Abdul Rahim Khan, Manuel De la Sen   +3 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Strong Convergence Theorems of Viscosity Iterative Methods for a Countable Family of Strict Pseudo-contractions in Banach Spaces

Fixed Point Theory and Applications, 2010
For a countable family of strictly pseudo-contractions, a strong convergence of viscosity iteration is shown in order to find a common fixed point of in either a p-uniformly convex Banach space which admits a weakly continuous duality mapping or a p-
Wangkeeree Rabian, Kamraksa Uthai
doaj  

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Existence Results of best Proximity Pairs for a Certain Class of Noncyclic Mappings in Nonreflexive Banach Spaces Polynomials

پژوهش‌های ریاضی, 2018
Introduction Let  be a nonempty subset of a normed linear space . A self-mapping  is said to be nonexpansive provided that  for all . In 1965, Browder showed that every nonexpansive self-mapping defined on a nonempty, bounded, closed and convex subset of
Moosa Gabeleh
doaj  

Strong Convergence of Cesàro Mean Iterations for Nonexpansive Nonself-Mappings in Banach Spaces

Fixed Point Theory and Applications, 2007
Let E be a real uniformly convex Banach space which admits a weakly sequentially continuous duality mapping from E to E*, C a nonempty closed convex subset of E which is also a sunny nonexpansive retract of E, and T:C→E a non-expansive nonself ...
Rabian Wangkeeree
doaj   +1 more source

Hölder continuous retractions and amenable semigroups of uniformly Lipschitzian mappings in Hilbert spaces [PDF]

Topological Methods in Nonlinear Analysis, 2016
Suppose that S is a left amenable semitopological semigroup. We prove that if ${T_{t}: t \in S}$ is a uniformly k-Lipschitzian semigroup on a bounded closed and convex subset C of a Hilbert space and ...
openaire   +3 more sources