Results 61 to 70 of about 3,082,536 (295)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Viability problem with perturbation in Hilbert space

Electronic Journal of Qualitative Theory of Differential Equations, 2007
This paper deals with the existence result of viable solutions of the differential inclusion $$\dot{x}(t) \in f(t,x(t)) + F(x(t))$$ $$x(t) \in K \quad \text{on } [0,T],$$ where $K$ is a locally compact subset in separable Hilbert space $H,$ $(f(s,\cdot))
A. Ait, S. Sajid
doaj   +1 more source

Adaptive Neural Event-Triggered Control of MIMO Pure-Feedback Systems With Asymmetric Output Constraints and Unmodeled Dynamics

IEEE Access, 2020
In this paper, the issue of adaptive neural event-triggered control (ETC) is studied for uncertain block-structure multi-input multi-output (MIMO) constrained non-affine nonlinear systems with unmodeled dynamics.
Yu Hua, Tianping Zhang
doaj   +1 more source

Mechanical, microstructural and fracture studies on inconel 825–SS316L functionally graded wall fabricated by wire arc additive manufacturing

Scientific Reports, 2023
This paper presents a novel method that uses the cold metal transfer based wire arc additive manufacturing process to fabricate functionally graded Inconel 825–SS316L walls.
T. S. Senthil, S. Ramesh Babu, M. Puviyarasan   +2 more
doaj   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Existence Theorems on Solvability of Constrained Inclusion Problems and Applications

Abstract and Applied Analysis, 2018
Let X be a real locally uniformly convex reflexive Banach space with locally uniformly convex dual space X⁎. Let T:X⊇D(T)→2X⁎ be a maximal monotone operator and C:X⊇D(C)→X⁎ be bounded and continuous with D(T)⊆D(C).
Teffera M. Asfaw
doaj   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Convergence Theorems for Infinite Family of Multivalued Quasi-Nonexpansive Mappings in Uniformly Convex Banach Spaces

Abstract and Applied Analysis, 2012
We introduce an iterative method for finding a common fixed point of a countable family of multivalued quasi-nonexpansive mapping {Ti} in a uniformly convex Banach space. We prove that under certain control conditions, the iterative sequence generated by
Aunyarat Bunyawat, Suthep Suantai
doaj   +1 more source

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source