Results 61 to 70 of about 59,818 (241)

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Assessing lagoon plume dispersion under variable metocean conditions

Frontiers in Environmental Engineering
Coastal lagoons are ecologically sensitive environments that are highly vulnerable to anthropogenic pressures and pollutant dispersal. Understanding how pollutants move within these systems lays the groundwork for managing water quality and mitigating ...
Mattia Scovenna, Giovanni Besio
doaj   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Uniformly continuous maps between ends of R-trees

, 2007
There is a well-known correspondence between infinite trees and ultrametric spaces which can be interpreted as an equivalence of categories and comes from considering the end space of the tree. In this equivalence, uniformly continuous maps between the end spaces are translated to some classes of coarse maps (or even classes of metrically proper ...
Pérez, Álvaro Martínez, Morón, M. A.
openaire   +2 more sources

Completion of merotopic spaces and extension of uniformly continuous maps

Topology and its Applications, 1983
AbstractA general Riesz merotopic space (X, ν) determines a not necessarily topological closure operator cν on X. The space (X, ν) is said to be complete if every cluster on (X, ν) is contained in an adherence grill on (X, cν). We discuss a method of obtaining a large class of completions of a given Riesz merotopic space with induced T1 closure space ...
Chattopadhyay, K.C., Njåstad, Olav
openaire   +2 more sources

The VHL tumor suppressor at the crossroad of protein folding, aggregation, and cancer

Molecular Oncology, EarlyView.
Mutations, environmental stress, and chaperone dysfunction can destabilize pVHL, promoting its conversion from the native folded state into amyloid‐like assemblies. This transition may contribute to protein storage, cell dormancy, survival, and drug resistance.
Lara Abad, Silvio Carlo Ermanno Tosatto, Emanuela Leonardi   +2 more
wiley   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Pan-cell type continuous chromatin state annotation of 1,698 epigenomes from the International Human Epigenome Consortium

Genome Biology
Background Building on primary data generated by its member consortia, the International Human Epigenome Consortium has uniformly processed a collection of more than 2,000 reference epigenomes profiling histone modifications, DNA methylation, and RNA ...
Habib Daneshpajouh, Ismail Moghul, Kay C. Wiese, Maxwell W. Libbrecht   +3 more
doaj   +1 more source

Time-Frequency Feature-Guided Progressive Attention DenseNet for Audio-Magnetotelluric Noise Detection

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
The audio-magnetotelluric (AMT) sounding method has been widely applied in mineral exploration and engineering geology. Unfortunately, field-observed signals are often contaminated by various random noises, causing the signal-to-noise ratio (SNR) to ...
Dian Hong, Jin Li, Jiayu Wang, Qunbin Qi, Jianmin Li, Jingtian Tang   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source