Results 111 to 120 of about 460,378 (314)

A Toolkit for Targeted Neuromodulation of Striatal Direct Pathway Neurons Rescues Parkinsonian Motor Deficits in Mice

Advanced Science, EarlyView.
An adeno‐associated virus (AAV) toolkit enables selective anatomical and functional targeting of striatal D1‐MSNs through retrograde transduction. Enhanced capsids and engineered enhancers drive robust transgene expression across murine and primate models.
Zexuan Hong, Yujing Zhang, Junjiao Zhang, Hanhe Liu, Qiwei Liu, Yanglei Li, Lixin Yang, Lixia Li, Zhongjie Liu, Zhen Yuan, Zhonghua Lu, Yefei Chen, Yuantao Li, Yuwu Jiang, Taian Liu   +14 more
wiley   +1 more source

Case Report: Unilateral relapsing primary central nervous system vasculitis—expanding the phenotype

Frontiers in Immunology
BackgroundUnilateral relapsing primary central nervous system vasculitis (UR-PCNSV) is a scarcely reported subtype of PCNSV. It is characterised by frequent relapses with lesions confined to a single hemisphere.
Turlough Montague, Jenny Han, Emily Cheung, James Drummond, Hwei Choo Soh, Jeannette Lechner-Scott, John Parratt   +6 more
doaj   +1 more source

Circular RNA circNrip1 Interacts with SYNCRIP to Promote Neuropathic Pain by Stabilizing Tlr2 mRNA in Primary Sensory Neurons

Advanced Science, EarlyView.
Model of circNrip1 (cNrip1) upregulation driving neuropathic pain mechanisms. After peripheral nerve injury, increased FUS triggers the formation and upregulation of cNrip1 in injured DRG neurons. Upregulated cNrip1 recruits SYNCRIP to the 3′‐UTR of Tlr2 mRNA by binding to both, thereby promoting SYNCRIP‐triggered Tlr2 mRNA stability and increasing ...
Xiaozhou Feng, Jifang Xiao, Congcong Huang, Bao‐Chun Jiang, Bing Wang, Xu Li, Shibin Du, Tolga Berkman, Chun‐Hsien Wen, Weihua Cai, Dilip Sharma, Kun Wang, Longfei Ma, Huijuan Hu, Yuan‐Xiang Tao   +14 more
wiley   +1 more source

Syringomyelia presenting with unilateral optic neuropathy: a case report

International Medical Case Reports Journal, 2017
Qi Zhe Ngoo, Evelyn Li Min Tai, Wan Hazabbah Wan Hitam Department of Ophthalmology, School of Medical Sciences, Universiti Sains Malaysia, Kubang Kerian, Malaysia Purpose: In this case report, we present two cases of syringomyelia with optic neuropathy ...
Ngoo QZ, Tai ELM, Wan Hitam WH
doaj  

Nigra‐Subthalamic Dopaminergic Circuitry Modulates and Represents Distinct Pain Modality in Physiological and Pain States in Mice

Advanced Science, EarlyView.
Nigral dopaminergic (DA) neurons modulate and represent pain with a preference to a particular modality (mechanical) and laterality (contralateral), which are controlled by nigral GABAergic neurons. The pain modulation is mimicked by the nigro‐subthalamic projection and its downstream neurons, involving D2‐like receptors.
Ying Ji, Shuyi Li, Jiaqi Zhang, Xiang‐Ying Xu, Cui Yin, Mu Niu, Danyang Liu, Yanyu Jiang, Yong Niu, Su Liu, Bin Zhang, Guiyun Cui, Chunyi Zhou, Cheng Xiao   +13 more
wiley   +1 more source

Mirror illusion reduces motor cortical inhibition in the ipsilateral primary motor cortex during forceful unilateral muscle contractions

, 2015
Forceful, unilateral contractions modulate corticomotor paths targeting the resting, contralateral hand. However, it is unknown if mirror-viewing of a slowly moving but forcefully contracting hand would additionally affect these paths.
Hortobágyi, Tibor, Thomas, Kevin, Goodall, Stuart, Howatson, Glyn, Hortobagyi, Tibor; id_orcid, Zult, Tjerk   +5 more
core   +1 more source

LIBERTIES - LEGAL ACT OF UNILATERAL OR BILATERAL TRAINING [PDF]

Challenges of the Knowledge Society, 2012
We analyzed liberality, special institution of civil law substantially in two particular aspects: legal document formation legal act unilaterally and bilaterally band. Every human life is a complex and irreversible phenomenon, which they flow, limited in
ANCA NICOLETA GHEORGHE, CAMELIA SPASICI
doaj  

Unilateral Exanthem

Indian Journal of Dermatology, 2015
Anisha George, Paulina Rose Chaudhary, Bimal Kanish   +2 more
openaire   +3 more sources

Dose‐Dependent Reprogramming of Chromatin Accessibility by SOX4 Drives the Transcriptional Response to Iron Overload

Advanced Science, EarlyView.
This study demonstrates that iron overload triggers widespread chromatin compaction and transcriptional repression in human granulosa cells, recapitulating features of endometriosis. The epigenetic reprogramming is orchestrated by a TFEB‐SOX4‐SWI/SNF axis, with SOX4 acting as a central, dosage‐sensitive regulator.
Feifei Li, Yaoqiu Wu, Guangyu Yang, Jingyi Lai, Xiaoyue Sun, Liyan Wang, Xiaoli Li, Jing Zhang, Qingxue Zhang, Hui Chen, Haiyan Lin, Bingxiang Xu, Junfeng Zhang, Hailong Wang, Anming Meng, Chunwei Cao   +15 more
wiley   +1 more source

La liquidación unilateral del contrato estatal

, 2016
La figura de la liquidación unilateral de los contratos estatales viene siendo tratada tanto en la noma como en la jurisprudencia y doctrina, sin embargo falta determinar si es componente de las cláusulas excepcionales o es potestad exorbitante de la ...
Arroyo Brevera, Jairo Alberto
core