Results 81 to 90 of about 103,180 (213)

Nuclear Translocation of PFKFB3 Promotes Disuse‐Induced Muscle Atrophy via Scaffolding Nedd4‐Mediated JunB Ubiquitination

Advanced Science, EarlyView.
Disuse‐induced muscle atrophy is driven by a non‐metabolic, nuclear function of the enzyme PFKFB3. Acting as a scaffold, PFKFB3 facilitates Nedd4‐mediated ubiquitination and degradation of the anti‐atrophy transcription factor JunB. Inhibiting this novel PFKFB3–Nedd4–JunB signaling axis stabilizes JunB and alleviates muscle wasting, revealing a highly ...
Mengjun Ma, Yinliang Liu, Wangchang Wu, Biao Yang, Jiahao Zhuang, Haoye Yu, Rujia Mi, Yixuan Lu, Wen Yang, Hanting Yi, Chenglong Yuan, Yinfeng Gu, Hongyu Li   +12 more
wiley   +1 more source

COMPARISON OF RADIOGRAPHIC PATTERNS OF KNEE OSTEOARTHRITIS IN TURKISH AND BRITISH PATIENTS: RELATIONSHIP BETWEEN SYMPTOMS AND DISABILITY

The Turkish Journal of Gastroenterology, 2004
Osteoarthritis, with different risk factors and classifications is a heterogenous disease. Symptoms poorly correlate with structural damage as seen on plain radiographs.
Nurdan Kotevoğlu, Nesrin Canik, Afitap İçağasıoğlu   +2 more
doaj  

Unilateral acute posterior multifocal placoid pigment epitheliopathy (APMPPE) with delayed contralateral eye involvement

BMC Ophthalmology
Background Acute posterior multifocal placoid pigment epitheliopathy (APMPPE) is a rare presumed inflammatory chorioretinopathy characterized by creamy, yellow-white placoid lesions at the level of the retinal pigment epithelium (RPE).
Emanuel Mordechaev, Gabriel Shakarov, Deep Parikh   +2 more
doaj   +1 more source

Case of Unilateral Linear Lichen Planus with Bilateral Mucosal Involvement

Journal of Primary Care Specialties
A form of lichen planus (LP) which follows the Blaschkos line pattern known as linear LP, presents with lichenoid eruptions and violaceous papules in a linear distribution. It is a rare form of LP affecting
Adarshlata Singh, Kaveri Rusia, Drishti Bhatt, Ambika Kondalkar, Bhushan Madke   +4 more
doaj   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

Beyond the Marrow: Unilateral Breast Involvement in Acute Lymphoblastic Leukemia

Current Research in MRI
Hematological malignancies involving the breast are exceedingly rare, accounting for less than 1% of all breast tumors. Breast infiltration by acute lymphoblastic leukemia (ALL) is particularly uncommon, with fewer than 25 cases reported in the ...
Ahmet Tuğrul Akkuş, Fadime Güven, Sare Sipal   +2 more
doaj   +1 more source

AI‐Designed TREM1‐Targeted LYTAC Nanoparticles Reprogram the Neuroimmune Microenvironment in Traumatic Brain Injury

Advanced Science, EarlyView.
AI‐enabled de novo design of a TREM1 binder, integrated into a BBB‐crossing and macrophage‐targeted nanoplatform, enables TREM1 degradation and attenuates neuroinflammation, thereby promoting neuroprotection and tissue repair after traumatic brain injury. ABSTRACT Secondary neuroinflammation drives progressive damage after traumatic brain injury (TBI),
Yimin Huang, Yuan Liu, Huan Peng, Yu Ni, Zhengqiao Jiang, Chenxuan Yu, Xincheng Zhang, Huayu Kang, Yanchao Liu, Juan Chen, Kai Zhao, Lin Han, Xin Zou, Kai Shu, Xiaochuan Wang, Jian‐Zhi Wang, Ting Lei, Chao Gan, Jianfeng Liu, Huaqiu Zhang   +19 more
wiley   +1 more source

PBRM1 Deficiency in Microglia Leads to Excessive Neurogenesis and Autism‐Like Behaviors via the CCL5‐CCR1/5‐β‐catenin Signaling Axis

Advanced Science, EarlyView.
Microglial PBRM1 deficiency drives excessive hippocampal neurogenesis by enhancing CCL5–CCR1/5 signaling, leading to autism‐like behaviors. A pro‐inflammatory IL1α+/TNFα+ microglial subset is identified as a key cellular contributor to this process. PBRM1 represses Ccl5 expression at the transcriptional level.
Yang‐Yang Duan, Lin‐Fei Jiao, Pei‐Pei Liu, Chun‐Hui Duan, Xiao Li, Zi‐Han Zhang, Yue‐Qi Zhang, Xin‐Li Ouyang, Hong‐Zhen Du, Sha Liu, Yi Tang, Zhao‐Qian Teng, Chang‐Mei Liu   +12 more
wiley   +1 more source

Lenz microphthalmic syndrome in an Indian patient

Indian Journal of Ophthalmology, 2007
A case of Lenz microphthalmia syndrome in a seven-month-old male child having features of unilateral anophthalmia, microcephaly, external ear and finger abnormalities, hydrocele and hypospadias is being reported.
Gupta Arvind, Srinivasan Renuka, Pandian Datta, Babu K   +3 more
doaj  

Unilateral retinitis pigmentosa in Von Recklinghausen disease: A rare occurrence

Indian Journal of Ophthalmology. Case Reports
Retinitis pigmentosa (RP) is hereditary progressive retinal dystrophy causing symmetrical affliction of both eyes. Neurofibromatosis 1 (NF1)/Von Recklinghausen disease is a hereditary neurocutaneous disorder with ocular involvement.
Kavin Bhogar, Taru Dewan, Kumari Ritu, Ishita Tyagi   +3 more
doaj   +1 more source