Results 81 to 90 of about 2,747,213 (281)

ZBTB18 Dysfunction Promotes Neuropathic Pain via CHD4‐based Epigenetic Disinhibition of CLIC1 Channels in Sensory Neurons

Advanced Science, EarlyView.
In this study, we identify a novel functional role of ZBTB18 in regulating trigeminal‐mediated neuropathic pain. Nerve injury reduces ZBTB18 in trigeminal ganglion neurons, impairing CHD4/NuRD recruitment and de‐repressing Clic1. Elevated CLIC1 enhances chloride channel activity and neuronal hyperexcitability, thereby driving pain.
Shoupeng Wang, Zitong Huang, Yu Tao, Yunmei Zhang, Yufang Sun, Dongsheng Jiang, Weiwei Lu, Fuhai Ji, Gang Chen, Min Xu, Yuan Zhang, Jin Tao   +11 more
wiley   +1 more source

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

Advanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen, Ying Ma, Lixuan Huang, Xin Chen, Fanliang Kong, Zhenzhou Qian, Mingyue Guan, Xinlin Wang, Yanyan Yang, Shasha Zhang, Peng Li, Renjie Chai   +11 more
wiley   +1 more source

Crossed Leg Sign Is Associated With Severity of Unilateral Spatial Neglect After Stroke

Frontiers in Neurology, 2018
BackgroundThe crossed leg sign in patients with right hemisphere stroke is thought to be associated with perceptual disorders, such as unilateral spatial neglect (USN).
Gustavo José Luvizutto, Eduardo de Moura Neto, Luiz Antônio de Lima Resende, Hélio Rubens de Carvalho Nunes, Luiz Eduardo Gomes Garcia Betting, Rodrigo Bazan   +5 more
doaj   +1 more source

Synergistic Regulation of Deep‐Cycling‐Induced Zn Pulverization and Resting Galvanic Corrosion in Practical Lean Zinc Anodes

Advanced Science, EarlyView.
Benzotriazole (BTA) regulates Zn reduction kinetics and suppresses galvanic corrosion, simultaneously mitigating Zn pulverization during cycling and self‐corrosion during storage, thereby enabling lean Zn anodes with enhanced cycling stability and extended calendar life.
Jing Xu, Haolin Li, Qiyin Jing, Lingfei Zhao, Elad Ballas, Bing Sun, Doron Aurbach, Guoxiu Wang   +7 more
wiley   +1 more source

Subclassification of unilateral spatial neglect

Higher Brain Function Research, 2006
ある基準によって区分された各項をさらに細かく分けることを下位分類という。半側無視を下位分類することは，局在診断の手段としての重要性のみならず，日常生活場面での問題点や対処法を明確にしていく必要性の上に成り立ち，完治とはいかないまでも，何らかの改善方策を見出す可能性へとつながるものである。本稿では半側無視の発現機序の解明や治療法の確立を期待して，いくつかの基準に基づいた分類を行った。すなわち，原因疾患からみた分類，半球優位性からみた分類，重症度の分類，病巣の違いによる分類，無視空間の違いによる分類，無視する感覚様式の違いによる分類，認知·遂行過程による分類，発現機序からみた分類などを行い，それらについて解説を加えた。
openaire   +2 more sources

Unilateral Spatial Neglect in Visual and Tactile Modalities

Cortex, 1991
The purpose of this study was to investigate whether a unilateral spatial neglect phenomenon occurs in the tactile modality in the absence of visual information. Ten patients with clinically confirmed visual spatial neglect and 10 normal controls bisected lines visually, or by touch when blindfolded.
T, Fujii, R, Fukatsu, I, Kimura, S, Saso, K, Kogure   +4 more
openaire   +2 more sources

A Gut‐Brain Axis Underlying Succinate‐Associated Compulsive‐Like Behavior

Advanced Science, EarlyView.
Gut‐derived succinate is associated with an excitatory‐inhibitory imbalance in dmPFC glutamatergic neurons, involving microglial SUCNR1 activation and vagal afferent signaling via upregulated gut 5‐HT4 receptors along the DVC‐CeA‐dmPFC circuit, changes that are linked to excessive compulsive‐like behavior.
Yi Li, Ying‐Dan Zhang, Wei Wang, Xin‐Yi Wu, Di Li, Xin Gong, Fei Tian, Meng‐Yu Dai, Jian Gao, Zi‐Feng Zheng, Zi‐Yang Bi, Dong‐Dong Shi, Zhen Wang   +12 more
wiley   +1 more source

Crossing the midline: reducing attentional deficits via interhemispheric interactions [PDF]

, 2005
Patients with unilateral neglect and extinction show a profound lack of awareness of stimuli presented contralateral to their lesion. However, many processes of perception are intact and contralesional stimuli seem to reach a high level of representation,
Brooks, JL, Robertson, LC, Robertson, Lynn C., Brooks, Joseph L, Wong, YT, Wong, Yuting   +5 more
core   +1 more source

Astrocytes Coordinate Neurovascular Coupling During Prolonged Sensory Demand via AQP4/TRPA1/BEST1/D‐Serine Signaling

Advanced Science, EarlyView.
Neuronal activation leads to astrocytic transient volume changes, activating transient receptor potential ankyrin 1 (TRPA1) channels, leading to Ca2+ influx. Activation of TRPA1 causes the release of D‐serine through BEST1. Finally, the augmented extracellular levels of D‐serine boost neuronal activity by binding GluN1‐containing NMDARs, leading to CBV
Kayoung Han, Minwoo Wendy Jang, Taeyoung Park, Ki Jung Kim, Victor James Drew, Sunpil Kim, Tai Young Kim, Mingu Gordon Park, Myeongju Kim, Seung Won Chung, Minah Suh, C. Justin Lee   +11 more
wiley   +1 more source

The automatic pilot of the hand is unbalanced by visual neglect [PDF]

, 2010
This article discusses the automatic pilot of the hand being unbalanced by visual ...
McIntosh, R.D., McIntosh, Robert D., Rossit, Stephanie, Monika Harvey, Butler, Stephen H., Malhotra, Paresh, McIntosh, Robert D, Paresh Malhotra, Butler, Stephen H, Harvey, M., Harvey, Monika, Stephanie Rossit, Butler, S.H., Robert D. McIntosh, Stephen H. Butler, Rossit, S., Malhotra, P.   +16 more
core   +1 more source