Results 61 to 70 of about 5,203,932 (313)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

O pace dureroasă, dar necesară. Alexandru Marghiloman şi Pacea de la Bucureşti – 27 aprilie/ 7 mai 1918 [PDF]

open access: yesDialogica: Revistă de Studii Culturale și Literatură
The Bucharest Peace Treaty, signed by Romania with Germany, Austria-Hungary, Bulgaria and Turkey on April 27/ May 7, 1918, during the First World War, was imposed on Romania as a result of Tsarist Russia’s withdrawal from the warand the real danger that ...
Mircea TĂNASE
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

INTERCONFESSIONAL INTERACTIONS ON THE TERRITORIES OF UKRAINE IN THE FIRST HALF OF XVI CENTURY AND THEIR EFFECTS ON EDUCATION AND CULTURE

open access: yesОсвітній дискурс, 2020
The article examines the spiritual and religious culture of Ukraine in the first half of the sixteenth century, which is one of the most interesting and poorly researched topics in the history of cultural development of Ukraine. It was during this period
Ruslana Mnozhynska
doaj   +1 more source

Hyperosmotic stress induces PARP1‐mediated HPF1‐dependent mono(ADP‐ribosyl)ation

open access: yesFEBS Letters, EarlyView.
Sorbitol‐induced hyperosmotic stress rapidly induces reversible mono(ADP‐ribosyl)ation (MARylation) on PARP1 without the signs of genotoxic signaling. We show that PARP1 autoMARylation is HPF1 dependent and forms hydroxylamine‐resistant O‐glycosidic linkages.
Anna Georgina Kopasz   +11 more
wiley   +1 more source

Report of the executive council on the audit of the union and the ministerial committee on the union government [PDF]

open access: yes, 2008
Assembly of the African Union Tenth Ordinary Session 31 January - 02 February 2008 Addis Ababa ...
African Union
core  

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

COMMUNIQUÉ ON THE MEETING BETWEEN THE CHAIRPERSON OF THE COMMISSION OF THE AFRICAN UNION AND THE MINISTER FOR FOREIGN AFFAIRS OF THE UNION OF THE COMOROS [PDF]

open access: yes, 2018
Addis Ababa, 3 June 2018: The Chairperson of the African Union Commission, Moussa Faki Mahamat, received, yesterday, the Minister for Foreign Affairs, International Cooperation and Francophonie, in charge of the Diaspora, of the Union of the Comoros ...
African Union
core  

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