Neuroactive steroids in depression and anxiety disorders: Clinical studies [PDF]
Certain neuroactive steroids modulate ligand-gated ion channels via non-genomic mechanisms. Especially 3 alpha-reduced pregnane steroids are potent positive allosteric modulators of the gamma-aminobutyric acid type A (GABA(A)) receptor.
Akwa Y +79 more
core +1 more source
Immune changes and predictors of response in patients with depression
Worldwide major depression is one of the most important reasons for years of life lost and years lived with disability. In Germany, more than 5 Million people suffer from unipolar or bipolar depression.
Martin Schaefer +4 more
doaj +1 more source
Monotherapy with major antihypertensive drug classes and risk of hospital admissions for mood disorders [PDF]
Major depressive and bipolar disorders predispose to atherosclerosis, and there is accruing data from animal model, epidemiological, and genomic studies that commonly used antihypertensive drugs may have a role in the pathogenesis or course of mood ...
Boal, Angela H. +6 more
core +1 more source
Background: Pramipexole is a dopamine full agonist approved for the treatment of Parkinson’s disease and restless legs syndrome. Its high affinity for the D3 receptor and neuroprotective, antioxidant, and anti-inflammatory activity provides a rationale ...
Antonio Tundo +6 more
doaj +1 more source
Maintenance deep transcranial magnetic stimulation sessions are associated with reduced depressive relapses in patients with unipolar or bipolar depression [PDF]
Introduction: Deep transcranial magnetic stimulation (dTMS) is a new form of TMS allowing safe stimulation of deep brain regions. The objective of this preliminary study was to assess the role of dTMS maintenance sessions in protecting patients with ...
ANGELETTI, Gloria +11 more
core +2 more sources
Early Maladaptive Schemas Related to Unipolar and Bipolar Depression: Similarities and Differences
Objective and methodology: Cognitive theory of depression has begun to examine the difference between bipolar and unipolar depression in the context of thinking features.
Nergis LAPSEKİLİ, Mehmet AK
doaj +1 more source
Salivary melatonin onset in youth at familial risk for bipolar disorder [PDF]
Melatonin secretion and polysomnography (PSG) were compared among a group of healthy adolescents who were at high familial risk for bipolar disorder (HR) and a second group at low familial risk (LR).
Armitage, Roseanne +13 more
core +2 more sources
Altered hippocampal function in major depression despite intact structure and resting perfusion [PDF]
Background: Hippocampal volume reductions in major depression have been frequently reported. However, evidence for functional abnormalities in the same region in depression has been less clear.
A. Finkelmeyer +18 more
core +2 more sources
Game changer in the diagnosis of bipolar disorder using RNA editing-based blood biomarkers
Introduction In clinical practice, differentiating Bipolar Disorder (BD) from unipolar depression is challenging due to the depressive symptoms, which are the core presentations of both disorders.
J.-D. Abraham +10 more
doaj +1 more source
Outcome Prediction for Unipolar Depression [PDF]
Although effective drug and non-drug treatment for unipolar depressive illness exist, different individuals respond differently to different treatments.
Cohen, Michael A. +3 more
core +1 more source

