Results 41 to 50 of about 1,145 (256)

On the unique solvability of the Runge-Kutta equations

open access: yesNumerische Mathematik, 1991
We consider the existence of a unique solution to the systems of equations that arise when we apply a Runge-Kutta method to a stiff nonlinear system of differential equations \(U'=f(t,U)\), with f satisfying a one-sided Lipschitz condition with constant \(\beta\).
Kraaijevanger, J.F.B.M., Schneid, J.
openaire   +1 more source

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

open access: yesFEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes   +4 more
wiley   +1 more source

On the boundary value problem for the loaded parabolic equations with irregular coefficients

open access: yesҚарағанды университетінің хабаршысы. Математика сериясы, 2018
In the paper we consider the generalized solvability of boundary value problem for the loaded parabolic equations with irregular coefficients. Theorem on unique solvability of the boundary value problem is proved.
M.T. Jenaliyev, A.S. Kassymbekova
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

open access: yesFEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura   +2 more
wiley   +1 more source

On the Unique Solvability of a Nonlinear Functional Evolution Equation

open access: yesJournal of Mathematical Analysis and Applications, 2002
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

On Uniqueness and Solvability in The Linear Problem of Ship Waves [PDF]

open access: yesThe Quarterly Journal of Mechanics and Applied Mathematics, 2009
This work is devoted to the question of uniqueness and solvability for the linear problem of ship waves, describing the forward motion of rigid totally submerged bodies in an unbounded fluid with a free surface. The statement of the problem is discussed with some attention paid to the conditions at infinity.
O. V. Motygin, P. Mciver
openaire   +1 more source

The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes

open access: yesFEBS Letters, EarlyView.
Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga   +3 more
wiley   +1 more source

An exact viscosity solution to a Hamilton–Jacobi–Bellman quasi-variational inequality for animal population management

open access: yesJournal of Mathematics in Industry, 2019
We formulate a stochastic impulse control model for animal population management and a candidate of exact solutions to a Hamilton–Jacobi–Bellman quasi-variational inequality.
Yuta Yaegashi   +3 more
doaj   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

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