Results 151 to 160 of about 3,546,472 (360)

Raphin‐1 mediates the survival and sensitivity to radiation of pediatric‐type diffuse high‐grade glioma via phosphorylated eukaryotic initiation factor 2α‐dependent and ‐independent processes

open access: yesMolecular Oncology, EarlyView.
Raphin‐1 reduces the survival of PED‐DHGG cells and enhances their radiation sensitivity through both PeIF2α‐dependent and PeIF2α‐independent mechanisms. Raphin‐1 sustains elevated levels of PeIF2α, contributing to its PeIF2α‐dependent effects. Additionally, raphin‐1 interacts with CReP to mediate a separate radiosensitizing pathway that operates ...
Karin Eytan   +4 more
wiley   +1 more source

Existence and Uniqueness of Solutions to Non-Local Problems of Brézis–Oswald Type and Its Application

open access: yesFractal and Fractional
The aim of this paper is to establish the existence and uniqueness of solutions to non-local problems involving a discontinuous Kirchhoff-type function via a global minimum principle of Ricceri.
Yun-Ho Kim
doaj   +1 more source

Machine learning for identifying liver and pancreas cancers through comprehensive serum glycopeptide spectra analysis: a case‐control study

open access: yesMolecular Oncology, EarlyView.
This study presents a novel AI‐based diagnostic approach—comprehensive serum glycopeptide spectra analysis (CSGSA)—that integrates tumor markers and enriched glycopeptides from serum. Using a neural network model, this method accurately distinguishes liver and pancreatic cancers from healthy individuals.
Motoyuki Kohjima   +6 more
wiley   +1 more source

An Exploration of the Qualitative Analysis of the Generalized Pantograph Equation with the q-Hilfer Fractional Derivative

open access: yesFractal and Fractional
This manuscript tries to show that there is only one solution to the problem of the q-Hilfer fractional generalized pantograph differential equations with a nonlocal condition, and it does so by employing a particular technique known as Schaefer’s fixed ...
R. Vivek   +4 more
doaj   +1 more source

β‐TrCP overexpression enhances cisplatin sensitivity by depleting BRCA1

open access: yesMolecular Oncology, EarlyView.
Low levels of β‐TrCP (Panel A) allow the accumulation of BRCA1 and CtIP, which facilitate the repair of cisplatin‐induced DNA damage via homologous recombination (HR) and promote tumor cell survival. In contrast, high β‐TrCP expression (Panel B) leads to BRCA1 and CtIP degradation, impairing HR repair, resulting in persistent DNA damage and apoptosis ...
Rocío Jiménez‐Guerrero   +8 more
wiley   +1 more source

Stability Analysis of Fractional-Order Nonlinear Alcohol Consumption Model and Numerical Simulation

open access: yesFractal and Fractional
This study explores the motivational factors behind alcohol consumption and its societal impacts. It identifies key reasons for drinking, such as improving sociability, boosting confidence, coping with challenges, participating in rituals, and seeking ...
Murugesan Sivashankar   +2 more
doaj   +1 more source

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