Results 151 to 160 of about 2,815,771 (370)

Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer

open access: yesMolecular Oncology, EarlyView.
mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia   +17 more
wiley   +1 more source

Most Convex Functions Have Unique Minimizers [PDF]

open access: yesarXiv, 2014
Finding the minimum and the minimizers of convex functions has been of primary concern in convex analysis since its conception. It is well-known that if a convex function has a minimum, then that minimum is global. The minimizers, however, may not be unique. There are certain subclasses, such as strictly convex functions, that do have unique minimizers
arxiv  

MET variants with activating N‐lobe mutations identified in hereditary papillary renal cell carcinomas still require ligand stimulation

open access: yesMolecular Oncology, EarlyView.
MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin   +14 more
wiley   +1 more source

Limit profiles and uniqueness of ground states to the nonlinear Choquard equations

open access: yesAdvances in Nonlinear Analysis, 2018
Consider nonlinear Choquard ...
Seok Jinmyoung
doaj   +1 more source

Peripheral blood leukocyte signatures as biomarkers in relapsed ovarian cancer patients receiving combined anti‐CD73/anti‐PD‐L1 immunotherapy in arm A of the NSGO‐OV‐UMB1/ENGOT‐OV30 trial

open access: yesMolecular Oncology, EarlyView.
Using mass cytometry, we analyzed serial blood samples from patients with relapsed epithelial ovarian cancer (EOC) treated with oleclumab–durvalumab combination immunotherapy in the NSGO‐OV‐UMB1/ENGOT‐OV30 trial. Our analysis identified potential predictive, monitoring, and response biomarkers detectable through liquid biopsy. These findings facilitate
Luka Tandaric   +11 more
wiley   +1 more source

Uniqueness Theorem for non-compact mean curvature flow with possibly unbounded curvatures [PDF]

open access: yesarXiv, 2017
In this paper, we discuss uniqueness and backward uniqueness for mean curvature flow of non-compact manifolds. We use an energy argument to prove two uniqueness theorems for mean curvature flow with possibly unbounded curvatures. These generalize the results by Chen and Yin. Using similar method, we also obtain a uniqueness result on Ricci flows.
arxiv  

Analysis of comprehensive genomic profiling of solid tumors with a novel assay for broad analysis in clinical diagnostics

open access: yesMolecular Oncology, EarlyView.
In molecular cancer diagnostics, comprehensive genomic profiling (CGP) is going to replace the small NGS panels since it provides all clinically relevant somatic variants as well as genomic biomarkers with clinical value. Here, we compared two CGP assays and demonstrate that the choice for diagnostic implementation will depend on the specific ...
Guy Froyen   +17 more
wiley   +1 more source

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