Results 151 to 160 of about 200,235 (314)
FEBS Open Bio, EarlyView.Matrix metalloproteinase‐9 (MMP9) drives ovarian cancer progression. Using MMP9‐null cells (M9‐KO) created from ovarian cancer cells, we found MMP9 loss did not block Epidermal Growth Factor (EGF)‐driven E‐cadherin dissolution or EMT but delayed and reduced EGF‐driven membrane protrusions. Transient MMP9 re‐expression drove membrane protrusion.
Claire Strauel +8 more
wiley +1 more source
FEBS Open Bio, EarlyView.Despite frogs avoiding low temperatures, examination of four salamander species revealed that none avoided cold and all possessed cold tolerance. Functional analysis of TRPM8, a cold sensor, showed that all salamander TRPM8s had lost their cold sensitivity.
Tadahiro Sawao +3 more
wiley +1 more source
Evolutionarily divergent DUF4465 domains have a common vitamin B12‐binding function
FEBS Open Bio, EarlyView.We show that DUF4465 family proteins, widespread across bacteria from gut microbiomes, hydrothermal vents, and soil, share a common vitamin B12‐binding function. These augmented β‐jellyroll proteins bind vitamin B12 via extended loops. Our findings establish sequence‐diverse DUF4465 proteins as a widespread class of B12‐binding proteins, highlighting ...
Charlea Clarke +4 more
wiley +1 more source
FEBS Open Bio, EarlyView.Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane +11 more
wiley +1 more source
Electronic Journal of Differential Equations, 2003 We prove existence and uniqueness of entropy solutions for the Cauchy problem of weakly coupled systems of nonlinear degenerate parabolic equations. We prove existence of an entropy solution by demonstrating that the Engquist-Osher finite difference ...
Helge Holden +2 more
doaj
Weak uniqueness of the navier-stokes equations and adaptive turbulence simulation
, 2005 We consider the problem of computational simulation of turbulence, where we study turbulent solutions to the incompressible Navier- Stokes equations. We construct approximate weak solutions using a stabilized Galerkin finite element method, here referred
Hoffman, Johan,
core
FEBS Open Bio, EarlyView.Bioscience students were asked for their opinions on the value and teaching of skills. 204 responded that teamwork, time management and study skills are necessary to reach University, that scientific writing, research, laboratory and presentation skills are taught effectively during their studies, while other skills are gained inherently through study ...
Janella Borrell, Susan Crennell
wiley +1 more source
Electronic Journal of Differential Equations, 2006 We provide conditions for the existence and uniqueness of positive solutions to the quasilinear elliptic system $$displaylines{ -Delta _{p}u=f(x,u,v) cr -Delta _{q}v=g(x,u,v) }$$ with Dirichlet boundary conditions on a bounded domain $Omega
Dimitrios A. Kandilakis +1 more
doaj
Long‐term hippocampal alterations and cognitive impairment in a murine model of surgical sepsis
FEBS Open Bio, EarlyView.Using a mouse model of surgical sepsis, we tested long‐term memory and analyzed the transcriptome of single cells isolated from the hippocampus. Survivor mice showed worse memory, loss of certain brain cell subpopulations, and abnormal immune cell activity—suggesting that post‐sepsis brain alterations may be linked to cognitive deficits.
Dong Seong Cho +4 more
wiley +1 more source
Meta-analysis reveals widespread negative associations between species richness and ecological uniqueness. [PDF]
Nat CommunChen Y +5 more
europepmc +1 more source