Results 161 to 170 of about 3,582,598 (362)

YAP1::TFE3 mediates endothelial‐to‐mesenchymal plasticity in epithelioid hemangioendothelioma

open access: yesMolecular Oncology, EarlyView.
The YAP1::TFE3 fusion protein drives endothelial‐to‐mesenchymal transition (EndMT) plasticity, resulting in the loss of endothelial characteristics and gain of mesenchymal‐like properties, including resistance to anoikis, increased migratory capacity, and loss of contact growth inhibition in endothelial cells.
Ant Murphy   +9 more
wiley   +1 more source

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

Multi‐omic profiling of squamous cell lung cancer identifies metabolites and related genes associated with squamous cell carcinoma

open access: yesMolecular Oncology, EarlyView.
Using multi‐omic characterization, we aimed to identify key regulators specific to squamous cell lung carcinoma (SqCC). SqCC‐specific differentially expressed genes were integrated with metabolics data. High expression of the creatine transporter SLC6A8, along with elevated creatine levels, appeared to be a distinct metabolic feature of SqCC.
Johan Staaf   +10 more
wiley   +1 more source

On uniqueness and existence of entropy solutions of weakly coupled systems of nonlinear degenerate parabolic equations

open access: yesElectronic Journal of Differential Equations, 2003
We prove existence and uniqueness of entropy solutions for the Cauchy problem of weakly coupled systems of nonlinear degenerate parabolic equations. We prove existence of an entropy solution by demonstrating that the Engquist-Osher finite difference ...
Helge Holden   +2 more
doaj  

In vitro properties of patient serum predict clinical outcome after high dose rate brachytherapy of hepatocellular carcinoma

open access: yesMolecular Oncology, EarlyView.
Following high dose rate brachytherapy (HDR‐BT) for hepatocellular carcinoma (HCC), patients were classified as responders and nonresponders. Post‐therapy serum induced increased BrdU incorporation and Cyclin E expression of Huh7 and HepG2 cells in nonresponders, but decreased levels in responders.
Lukas Salvermoser   +14 more
wiley   +1 more source

Existence and uniqueness results of positive solutions for nonvariational quasilinear elliptic systems

open access: yesElectronic Journal of Differential Equations, 2006
We provide conditions for the existence and uniqueness of positive solutions to the quasilinear elliptic system $$displaylines{ -Delta _{p}u=f(x,u,v) cr -Delta _{q}v=g(x,u,v) }$$ with Dirichlet boundary conditions on a bounded domain $Omega
Dimitrios A. Kandilakis   +1 more
doaj  

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