Results 31 to 40 of about 108,125 (249)
Molecular Oncology, EarlyView.We developed and validated a DNA methylation–based biomarker panel to distinguish pleural mesothelioma from other pleural conditions. Using the IMPRESS technology, we translated this panel into a clinically applicable assay. The resulting two classifier models demonstrated excellent performance, achieving high AUC values and strong diagnostic accuracy.
Janah Vandenhoeck +12 more
wiley +1 more source
On nonexistence of strongly unique best approximations
Journal of Mathematical Analysis and Applications, 1989 The author proves the following theorems: If M is an n-dimensional subspace of a real normed linear space X and if \(x\in X\setminus M\) and \(m\in M\) are such that \(\dim F(x-m)\leq n\) (where \(F(z)=\{f\in X^*:\quad \| f\| =1,\quad f(z)=\| z\| \}),\) then m is not a strongly unique best approximation in M to x.
openaire +2 more sources
Best Approximation by Free Knot Splines [PDF]
, 1998 We consider the problem of finding the best (uniform) approximation of a given continuous function by spline functions with free knots. Our approach can be sketched as follows: By using the Gauß transform with arbitrary positive real parameter t, we map ...
Meinardus, Günter, Walz, Guido
core
Generalized Separable Nonnegative Matrix Factorization
, 2019 Nonnegative matrix factorization (NMF) is a linear dimensionality technique for nonnegative data with applications such as image analysis, text mining, audio source separation and hyperspectral unmixing.
Gillis, Nicolas, Pan, Junjun
core +1 more source
Molecular Oncology, EarlyView.We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto +8 more
wiley +1 more source
Stability and computational analysis of Influenza-A epidemic model through double time delay
Alexandria Engineering JournalDelay factors demonstration has a significant role in controlling a strain of infectious disease instead of a pharmaceutical strategy. According to the World Health Organization (WHO), 3–5 million cases are reported annually and approximately 290,000 to ...
Ateq Alsaadi +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Small Winding-Number Expansion: Vortex Solutions at Critical Coupling
, 2015 We study an axially symmetric solution of a vortex in the Abelian-Higgs model at critical coupling in detail. Here we propose a new idea for a perturbative expansion of a solution, where the winding number of a vortex is naturally extended to be a real ...
Ohashi, Keisuke
core +1 more source
Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Molecular Oncology, EarlyView.The LINC01116 long noncoding RNA is induced by hypoxia and associated with poor prognosis and high recurrence rates in two cohorts of lung adenocarcinoma patients. Here, we demonstrate that besides its expression in cancer cells, LINC01116 is markedly expressed in lymphatic endothelial cells of the tumor stroma in which it participates in hypoxia ...
Marine Gautier‐Isola +12 more
wiley +1 more source