Results 71 to 80 of about 1,072,963 (337)

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

The Impact of Human Resource Practices on Business-Unit Operating and Financial Performance [PDF]

, 2002
This study examined the impact of HR practices and organizational commitment on business-unit operating performance and profitability. Using a predictive design with a sample of 50 autonomous business-units within the same corporation, the study revealed
Gardner, Timothy M., Moynihan, Lisa M., Wright, Patrick M.   +2 more
core   +1 more source

The neural crest‐associated gene ERRFI1 is involved in melanoma progression and resistance toward targeted therapy

Molecular Oncology, EarlyView.
ERRFI1, a neural crest (NC)‐associated gene, was upregulated in melanoma and negatively correlated with the expression of melanocytic differentiation markers and the susceptibility of melanoma cells toward BRAF inhibitors (BRAFi). Knocking down ERRFI1 significantly increased the sensitivity of melanoma cells to BRAFi.
Nina Wang, Qian Sun, Daniel Novak, Lei Zhu, Juliane Poelchen, Tamara Steinfass, Yiman Wang, Viktor Umansky, Jochen Utikal   +8 more
wiley   +1 more source

Reliability-Constrained Unit Commitment Considering Interruptible Load Participation

Iranian Journal of Electrical and Electronic Engineering, 2007
From the optimization point of view, an optimum solution of the unit commitment problem with reliability constraints can be achieved when all constraints are simultaneously satisfied rather than sequentially or separately satisfying them.
F. Aminifar, M. Fotuhi-Firuzabad
doaj  

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Metaheuristic Optimization in Dynamic Unit Commitment of Power Systems: Current Trends and Future Prospects

JOIV: International Journal on Informatics Visualization
This paper discusses various optimization algorithms, a mathematics and computer science method essential to solving challenging real-world problems. The presented real-world scenario centers on a power system with dynamic unit commitment.
Lilis Widayanti, Arif Nur Afandi, Heru Wahyu Herwanto, Vivi Aida Fitria   +3 more
doaj   +1 more source

Flexible Robust Risk-Constrained Unit Commitment of Power System Incorporating Large Scale Wind Generation and Energy Storage

IEEE Access, 2020
With the increasing penetration of wind power in the power systems, the uncertainties in wind power significantly challenge the reliable and economic operation of power systems.
Gaohang Zhang, Fengting Li, Chao Xie
doaj   +1 more source

Optimum generation scheduling incorporating wind energy using HHO–IGWO algorithm

Journal of Electrical Systems and Information Technology, 2023
Recently, renewable energy participation is gaining importance in the existing power system. However, the large penetration of these renewable energy sources into the existing power system network may cause an imbalance in supply and demand response ...
Dinesh Dhawale, Vikram Kumar Kamboj, Priyanka Anand   +2 more
doaj   +1 more source