Results 61 to 70 of about 17,401,899 (301)

COVID-19–Related Fatalities and Intensive-Care-Unit Admissions by Age Groups in Europe: A Meta-Analysis

Frontiers in Medicine, 2021
Objectives: Precise international estimates of the age breakdown of COVID-19–related deaths and intensive-care-unit (ICU) admissions are lacking. We evaluated the distribution of COVID-19–related fatalities and ICU admissions by age groups in Europe ...
Jérémie F. Cohen, Jérémie F. Cohen, Daniël A. Korevaar, Soraya Matczak, Martin Chalumeau, Martin Chalumeau, Slimane Allali, Julie Toubiana   +7 more
doaj   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

$\alpha$-Projectable and laterally $\alpha$-complete Archimedean lattice-ordered groups with weak unit via topology [PDF]

Categories and General Algebraic Structures with Applications
Let $\bf{W}$ be the category of Archimedean lattice-ordered groups with weak order unit, $\bf{Comp}$ the category of compact Hausdorff spaces, and $\mathbf{W} \xrightarrow{Y} \mathbf{Comp}$ the Yosida functor, which represents a $\bf{W}$-object $A$ as ...
Brian Wynne, Anthony Hager
doaj   +1 more source

By dawn or dusk—how circadian timing rewrites bacterial infection outcomes

FEBS Letters, EarlyView.
The circadian clock shapes immune function, yet its influence on infection outcomes is only beginning to be understood. This review highlights how circadian timing alters host responses to the bacterial pathogens Salmonella enterica, Listeria monocytogenes, and Streptococcus pneumoniae revealing that the effectiveness of immune defense depends not only
Devons Mo, Catherine S. Palmer, Jacqueline M. Kimmey   +2 more
wiley   +1 more source

Unit groups of cube radical zero commutative completely primary finite rings

International Journal of Mathematics and Mathematical Sciences, 2005
A completely primary finite ring is a ring R with identity 1≠0 whose subset of all its zero-divisors forms the unique maximal ideal J. Let R be a commutative completely primary finite ring with the unique maximal ideal J such that J3=(0) and J2≠(0). Then
Chiteng'a John Chikunji
doaj   +1 more source

Structural insights into lacto‐N‐biose I recognition by a family 32 carbohydrate‐binding module from Bifidobacterium bifidum

FEBS Letters, EarlyView.
Bifidobacterium bifidum establishes symbiosis with infants by metabolizing lacto‐N‐biose I (LNB) from human milk oligosaccharides (HMOs). The extracellular multidomain enzyme LnbB drives this process, releasing LNB via its catalytic glycoside hydrolase family 20 (GH20) lacto‐N‐biosidase domain.
Xinzhe Zhang, Naoki Sunagawa, Toma Kashima, Kiyohiko Igarashi, Akimasa Miyanaga, Shinya Fushinobu   +5 more
wiley   +1 more source

Internal in-frame translation generates Cas11b, which is important for effective interference in an archaeal CRISPR-Cas system

Frontiers in Microbiology
CRISPR-Cas is a sophisticated defence system used by bacteria and archaea to fend off invaders. CRISPR-Cas systems vary in their Cas protein composition and have therefore been divided into different classes and types.
A-L. Sailer, J. Brendel, A. Chernev, A. Chernev, S. König, S. König, T. Bischler, T. Gräfenhan, H. Urlaub, H. Urlaub, U. Gophna, A. Marchfelder   +11 more
doaj   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Structure of the unit group of the group algebras of non-metabelian groups of order 128 [PDF]

Mathematica Bohemica
We characterize the unit group for the group algebras of non-metabelian groups of order 128 over the finite fields whose characteristic does not divide the order of the group.
Navamanirajan Abhilash, Elumalai Nandakumar, Rajendra Kumar Sharma, Gaurav Mittal   +3 more
doaj   +1 more source