Results 71 to 80 of about 648,162 (256)

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Nilpotence and descent in equivariant stable homotopy theory

, 2016
Let $G$ be a finite group and let $\mathscr{F}$ be a family of subgroups of $G$. We introduce a class of $G$-equivariant spectra that we call $\mathscr{F}$-nilpotent.
Mathew, Akhil, Naumann, Niko, Noel, Justin   +2 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Synthesis of Unsymmetrically Condensed Benzo- and Thienotriazologermoles

Molecules
Germoles and siloles unsymmetrically condensed with heteroaromatic units are attracting much interest. In this study, compounds containing a triazologermole core unit condensed with a benzene or thiophene ring were prepared.
Cong-Huan Wang, Yohei Adachi, Joji Ohshita   +2 more
doaj   +1 more source

Synthesis, crystal structure at 219 K and Hirshfeld surface analyses of 1,4,6-trimethylquinoxaline-2,3(1H,4H)-dione monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The asymmetric unit of the title compound, C11H12N2O2·H2O, contains a molecule of 1,4,6-trimethyl-1,4-dihydroquinoxaline-2,3-dione and a solvent water molecule. Four atoms of the benzene ring are disordered over two sets of sites in a 0.706 (7):0.294 (7)
Ayman Zouitini, Md. Serajul Haque Faizi, Younes Ouzidan, Fouad Ouazzani Chahdi, Jérôme Marrot, Damien Prim, Necmi Dege, Ashraf Mashrai   +7 more
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Crystal structure, Hirshfeld surface analysis and DFT studies of 1,3-bis[2-methoxy-4-(prop-2-en-1-yl)phenoxy]propane

Acta Crystallographica Section E: Crystallographic Communications, 2020
The asymmetric unit of the title compound, C23H28O4, comprises two half-molecules, with the other half of each molecule being completed by the application of twofold rotation symmetry.
Abdelmaoujoud Taia, Mohamed Essaber, Tuncer Hökelek, Abdeljalil Aatif, Joel T. Mague, Ali Alsalme, Nabil Al-Zaqri   +6 more
doaj   +1 more source

Partial normalizations of coxeter arrangements and discriminants [PDF]

, 2012
We study natural partial normalization spaces of Coxeter arrangements and discriminants and relate their geometry to representation theory. The underlying ring structures arise from Dubrovin’s Frobenius manifold structure which is lifted (without unit ...
D. Mond, J.M. Granger, M. Schulze
core   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Csoportgyűrűk = Group rings [PDF]

, 2012
A következő témakörökben értünk el eredményeket: - algebrák reprezentációelmélete (vizsgáltuk Lie-algebrák burkoló algebrájának filteres multiplikatív bázisát) - véges csoportok reprezentációelmélete és az egész számok feletti csoportgyűrűk ...
Bódi, Béla, Bódi, Viktor
core