Results 71 to 80 of about 854,924 (287)

Stochastic bursting in unidirectionally delay-coupled noisy excitable systems

, 2019
We show that \emph{stochastic bursting} is observed in a ring of unidirectional delay-coupled noisy excitable systems, thanks to the combinational action of time-delayed coupling and noise.
Pikovsky, Arkady, Zheng, Chunming
core   +1 more source

ShcD adaptor protein drives invasion of triple negative breast cancer cells by aberrant activation of EGFR signaling

Molecular Oncology, EarlyView.
We identified adaptor protein ShcD as upregulated in triple‐negative breast cancer and found its expression to be correlated with reduced patient survival and increased invasion in cell models. Using a proteomic screen, we identified novel ShcD binding partners involved in EGFR signaling pathways.
Hayley R. Lau, Hayley S. Smith, Begüm Alural, Claire E. Martin, Laura A. New, Manali Tilak, Sara L. Banerjee, Hannah N. Robeson, Nicolas Bisson, Anne‐Claude Gingras, Jasmin Lalonde, Nina Jones   +11 more
wiley   +1 more source

Dieudonn\'e modules and $p$-divisible groups associated with Morava $K$-theory of Eilenberg-Mac Lane spaces [PDF]

, 2005
We study the structure of the formal groups associated to the Morava $K$-theories of integral Eilenberg-Mac Lane spaces. The main result is that every formal group in the collection $\{K(n)^*K({\mathbb Z}, q), q=2,3,...\}$ for a fixed $n$ enters in it ...
Andrey Lazarev, Buchstaber, Demazure, Goerss, Mac Lane, Manin, Novikov, Oort, Pierce, Quillen, Sadofsky, Shatz, Tate, Victor M Buchstaber   +13 more
core   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Deep neural network-based automatic metasurface design with a wide frequency range

Scientific Reports, 2021
Beyond the scope of conventional metasurface, which necessitates plenty of computational resources and time, an inverse design approach using machine learning algorithms promises an effective way for metasurface design.
Fardin Ghorbani, Sina Beyraghi, Javad Shabanpour, Homayoon Oraizi, Hossein Soleimani, Mohammad Soleimani   +5 more
doaj   +1 more source

Landscape of BRAF transcript variants in human cancer

Molecular Oncology, EarlyView.
We investigate the annotation of BRAF variants, focusing on protein‐coding BRAF‐220 (formerly BRAF‐reference) and BRAF‐204 (BRAF‐X1). The IsoWorm pipeline allows us to quantify these variants in human cancer, starting from RNA‐sequencing data. BRAF‐204 is more abundant than BRAF‐220 and impacts patient survival.
Maurizio S. Podda, Danilo Tatoni, Gianluca Mattei, Alberto Magi, Romina D'Aurizio, Laura Poliseno   +5 more
wiley   +1 more source

Pólya fields and Kuroda/Kubota unit formula

Mathematics Open, 2023
Let K be a number field. The Pólya field concept is used to know when the module of integer-valued polynomials over the ring of integers [Formula: see text] of K has a regular basis. In [C. W.-W.
Charles Wend-Waoga Tougma
doaj   +1 more source

Non-circular Gas Kinematics and Star Formation in the Ringed Galaxy NGC 4736

, 2000
We analyze the gas kinematics and star formation properties of the nearby RSab galaxy NGC 4736 using interferometric and single-dish CO(1-0) data and previously published Halpha and HI data.
Aalto S., Athanassoula E., Begeman K. G., Block D. L., Block D. L., Bloemen J. B. G. M., Bosma A., Braun R., Buta R., Combes F., Dahmen G., Elmegreen B. G., Friedli D., Friedli D., Gerin M., Heckman T. M., Huchtmeier W. K., Kimura T., Kotilainen J. K., Laine S., Leo Blitz, Louis P. D., Mollenhoff C., Mulder P. S., Mulder P. S., Roche P. F., Shioya Y., Steer D. G., Strong A. W., Tony Wong, van der Kruit P. C., van der Kruit P. C.   +31 more
core   +1 more source

A nucleotide‐independent, pan‐RAS‐targeted DARPin elicits anti‐tumor activity in a multimodal manner

Molecular Oncology, EarlyView.
We report a Designed Ankyrin Repeat Protein that binds and inhibits RAS proteins, which serve as central cell signaling hubs and are essential for the progression of many cancers. Its unique feature is that it does not discriminate between different RAS isoforms or mutations and is capable of binding to RAS in both its active (GTP‐bound) and inactive ...
Jonas N. Kapp, Wouter P. R. Verdurmen, Jonas V. Schaefer, Kari Kopra, Gabriela Nagy‐Davidescu, Elodie Richard, Marie‐Julie Nokin, Patrick Ernst, Rastislav Tamaskovic, Martin Schwill, Ralph Degen, Claudia Scholl, David Santamaria, Andreas Plückthun   +13 more
wiley   +1 more source

Crystal structure and optical spectroscopic analyses of (E)-3-(1H-indol-2-yl)-1-(4-nitrophenyl)prop-2-en-1-one hemihydrate

Acta Crystallographica Section E: Crystallographic Communications, 2018
The asymmetric unit of the title compound, 2C17H12N2O3·H2O comprises two molecules of (E)-3-(1H-indol-2-yl)-1-(4-nitrophenyl)prop-2-en-1-one and a water molecule. The main molecule adopts an s-cis configuration with respect to the C=O and C=C bonds.
Muhamad Fikri Zaini, Ibrahim Abdul Razak, Wan Mohd Khairul, Suhana Arshad   +3 more
doaj   +1 more source