Results 71 to 80 of about 646,677 (257)

Metformin promotes mitochondrial integrity through AMPK‐signaling in Leber's hereditary optic neuropathy

FEBS Open Bio, EarlyView.
Metformin mediates mitochondrial quality control in Leber's hereditary optic neuropathy (LHON) fibroblasts carrying mtDNA mutations. At therapeutic levels, metformin activates AMPK signaling to restore mitochondrial dynamics by promoting fusion and restraining fission, while preserving mitochondrial mass, enhancing autophagy/mitophagy and biogenesis ...
Chatnapa Panusatid, Rapasviranda Soiyangsuk, Maneeluck Tanadjindarat, Chayanon Peerapittayamongkol   +3 more
wiley   +1 more source

Partial normalizations of coxeter arrangements and discriminants [PDF]

, 2012
We study natural partial normalization spaces of Coxeter arrangements and discriminants and relate their geometry to representation theory. The underlying ring structures arise from Dubrovin’s Frobenius manifold structure which is lifted (without unit ...
D. Mond, J.M. Granger, M. Schulze
core   +1 more source

Motivic Landweber exact theories and their effective covers

, 2015
Let $k$ be a field of characteristic zero and let $(F,R)$ be a Landweber exact formal group law. We consider a Landweber exact $T$-spectrum $\mathcal{E}:=R\otimes_{\mathbb{L}}\text{MGL}$ and its effective cover $f_0\mathcal{E}\to \mathcal{E}$ with ...
Levine, Marc
core   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

Synthesis of Unsymmetrically Condensed Benzo- and Thienotriazologermoles

Molecules
Germoles and siloles unsymmetrically condensed with heteroaromatic units are attracting much interest. In this study, compounds containing a triazologermole core unit condensed with a benzene or thiophene ring were prepared.
Cong-Huan Wang, Yohei Adachi, Joji Ohshita   +2 more
doaj   +1 more source

Crystal structure, Hirshfeld surface analysis and DFT study of (2Z)-2-(4-fluorobenzylidene)-4-(prop-2-yn-1-yl)-3,4-dihydro-2H-1,4-benzothiazin-3-one

Acta Crystallographica Section E: Crystallographic Communications, 2019
The title compound, C18H12FNOS, is built up from a 4-fluorobenzylidene moiety and a dihydrobenzothiazine unit with a propynyl substituent, with the heterocyclic portion of the dihydrobenzothiazine unit adopting a shallow boat conformation with the ...
Brahim Hni, Nada Kheira Sebbar, Tuncer Hökelek, Younes Ouzidan, Ahmed Moussaif, Joel T. Mague, El Mokhtar Essassi   +6 more
doaj   +1 more source

Meta‐analysis fails to show any correlation between protein abundance and ubiquitination changes

FEBS Open Bio, EarlyView.
We analyzed over 50 published proteomics datasets to explore the relationship between protein levels and ubiquitination changes across multiple experimental conditions and biological systems. Although ubiquitination is often associated with protein degradation, our analysis shows that changes in ubiquitination do not globally correlate with changes in ...
Nerea Osinalde, Unai Alduntzin, Gorka Prieto, Ugo Mayor   +3 more
wiley   +1 more source

Synthesis, crystal structure at 219 K and Hirshfeld surface analyses of 1,4,6-trimethylquinoxaline-2,3(1H,4H)-dione monohydrate

Acta Crystallographica Section E: Crystallographic Communications, 2020
The asymmetric unit of the title compound, C11H12N2O2·H2O, contains a molecule of 1,4,6-trimethyl-1,4-dihydroquinoxaline-2,3-dione and a solvent water molecule. Four atoms of the benzene ring are disordered over two sets of sites in a 0.706 (7):0.294 (7)
Ayman Zouitini, Md. Serajul Haque Faizi, Younes Ouzidan, Fouad Ouazzani Chahdi, Jérôme Marrot, Damien Prim, Necmi Dege, Ashraf Mashrai   +7 more
doaj   +1 more source

Csoportgyűrűk = Group rings [PDF]

, 2012
A következő témakörökben értünk el eredményeket: - algebrák reprezentációelmélete (vizsgáltuk Lie-algebrák burkoló algebrájának filteres multiplikatív bázisát) - véges csoportok reprezentációelmélete és az egész számok feletti csoportgyűrűk ...
Bódi, Béla, Bódi, Viktor
core  

K-theory Classification of Graded Ultramatricial Algebras with Involution

, 2018
We consider a generalization $K_0^{\operatorname{gr}}(R)$ of the standard Grothendieck group $K_0(R)$ of a graded ring $R$ with involution. If $\Gamma$ is an abelian group, we show that $K_0^{\operatorname{gr}}$ completely classifies graded ...
Hazrat, Roozbeh, Vas, Lia
core   +1 more source