Results 31 to 40 of about 4,424,207 (254)

Specialists in the United States [PDF]

open access: yesBMJ, 1995
EDITOR,—I was trained in general surgery in Britain and then spent 10 years training surgical residents in the United States. Having observed the results of this method for the past 15 years in private surgical practice, I can vouch for the fact that it is possible to train bright medical graduates to a high standard of specialist competence in ...
openaire   +2 more sources

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

open access: yesFEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

Farmers' bulletin (United States. Dept. of Agriculture); no. 1689

open access: yes, 1932
"Three types of grapes are grown in the United States. In the order of economic importance they are vinifera, the American euvitis, and the muscadine. This bulletin sets forth in a general way the main geographic regions where these are found and makes ...
Husmann, George C. (George Charles Frederick), 1861-1939
core  

Farmers' bulletin (United States. Dept. of Agriculture)

open access: yes, 1941
Describes diseases and other problems affecting trees in farm woodlands of the eastern United States.
United States. Forest Service.   +3 more
core   +1 more source

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Coal-Mine Fatalities in the United States

open access: yes, 1920
Supplementary report published by the U.S. Bureau of Mines regarding fatalities in coal mines located in the United States: "In addition to giving monthly fatality tables for 1919, this report includes several tables that were published in various ...
Fay, Albert H.   +1 more
core  

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Farmers' bulletin (United States. Dept. of Agriculture)

open access: yes, 1942
Describes varieties of the winter legumes used for "green manure" in the southern United States; provides suggestions for considerations to make when using winter legumes on ...
McNair, A. D.   +2 more
core  

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