Results 41 to 50 of about 1,631,621 (208)

Septin 9 PB domains coordinate centrosome positioning and microtubule acetylation to control epithelial polarity

open access: yesFEBS Letters, EarlyView.
Septin 9 polybasic domains couple phosphoinositide‐rich membrane binding to centrosome positioning, Golgi organization, and microtubule acetylation to control epithelial polarity. Their loss disrupts this axis, causing centrosome mispositioning, Golgi fragmentation, reduced microtubule acetylation, and polarity inversion via upregulation of the ...
Ting ting Cai   +4 more
wiley   +1 more source

Public Management of Big Data: Historical Lessons from the 1940s

open access: yesFederal History, 2015
This article examines the use of Census Bureau data in 1942 to remove Japanese Americans to internment camps for the duration of World War II. Census data constituted the largest collection of data on Americans at that time.
Margo Anderson
doaj  

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

open access: yesFEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

The American People and the New Deal

open access: yesFederal History, 2009
Analysis of the Popular Front created by Franklin Roosevelt during the New Deal in which he was able to appeal to a broad spectrum of society across class, socioeconomic, religious, and political lines.
Michael Kazan
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

The National Nanotechnology Initiative Approach to Environment, Health, and Safety: A Model for Future Science Investments

open access: yesFederal History, 2016
This article discusses the very recent story about the new science of nanotechnology and the careful and clear-headed efforts to regulate it. Nanotechnology offers great promise in numerous applications, including national security, but can also raise ...
Brandi L. Schottel, Barbara Karn
doaj  

Phosphoinositides and inositol phosphates as molecular glues

open access: yesFEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry   +9 more
wiley   +1 more source

Postdramatic Theatre and Postdramatic Performance

open access: yesRevista Brasileira de Estudos da Presença, 2015
Beginning with the concept of a postdramatic theatre as articulated by the German theorist Hans-Thies Lehmann, this essay considers the recent work of several major international directors – Ivo van Hove, Punchdrunk, Signa and others – as examples of ...
Marvin Carlson (The City University of New York – New York, United States of America)
doaj  

Legal Issues Associated with Antimicrobial Drug Resistance

open access: yesEmerging Infectious Diseases, 1998
An effective public health strategy against the development of antimicrobial drug resistance needs to be informed by legal as well as scientific analysis.
David P. Fidler
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

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