Results 71 to 80 of about 4,424,207 (254)

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

The United States We Will Live In

open access: yes, 1945
Front: The text highlights what happened in the first weeks of the occupation of Japan. Photographs: General MacArthur receives Emperor Hirohito at the U.S.
[United States.] Army Information Branch.
core  

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

Farmers' bulletin (United States. Dept. of Agriculture) ; no. 2157

open access: yes, 1961
This bulletin discusses the cultivation of muscadine grapes in the southern United States. Topics discussed include propagation, pruning and training, soil management, fertilizers, harvesting, common diseases, and ...
United States. Agricultural Research Service. Crops Research Division.
core  

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Farmers' bulletin (United States. Dept. of Agriculture)

open access: yes, 1930
An illustrated guide to lesser-known but valuable non-native grass varieties in the United ...
Piper, Charles V. (Charles Vancouver), 1867-1926   +1 more
core  

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

Farmers' bulletin (United States. Dept. of Agriculture) ; no. 2157 (rev.)

open access: yes, 1971
Revised edition. This bulletin discusses the cultivation of muscadine grapes in the southern United States. Topics discussed include propagation, pruning and training, soil management, fertilizers, harvesting, common diseases, and ...
United States. Agricultural Research Service. Plant Science Research Division.
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

United States Bureau of Mines Bulletin 617

open access: yes, 1963
Supplementary report from the U.S. Bureau of Mines regarding the results of a survey of the natural gas (helium) resources available in the United States.
Munnerlyn, R. D.   +2 more
core  

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