Results 41 to 50 of about 12,745,617 (300)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

United States Environmental Protection Agency

, 2017
Case study abut the United States Environmental Protection Agency's use of the Altmetric Explorer for Institutions.
openaire   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Synergistic perspectives—How single‐molecule biophysics complement biochemical understanding

FEBS Letters, EarlyView.
In this review, we discuss how ensemble biochemistry and single‐molecule approaches are complementary, outline commonly used single‐molecule techniques, and illustrate their relevance through two representative case studies: chromatin organization by SMC complexes and pathway choice during DNA double‐strand break repair.
Sara De Bragança, Eline L. Jansen, Jorine M. Eeftens   +2 more
wiley   +1 more source

United States Environmental Protection Agency

, 2019
The mission of United States Environmental Protection Agency (EPA) is to protect human health and the environment and to ensure that Americans have clean air, land and water, as well as to promote national efforts to reduce environmental risks are based ...
United States Environmental Protection Agency
core   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

Photochemical grid model implementation and application of VOC, NO_x, and O₃ source apportionment [PDF]

Geoscientific Model Development, 2015
For the purposes of developing optimal emissions control strategies, efficient approaches are needed to identify the major sources or groups of sources that contribute to elevated ozone (O3) concentrations.
R. H. F. Kwok, K. R. Baker, S. L. Napelenok, G. S. Tonnesen   +3 more
doaj   +1 more source

Development of the United States Environmental Protection Agency’s Facilities Status Dashboard for the COVID-19 Pandemic: Approach and Challenges

International Journal of Public Health, 2022
Objectives: Develop a tool for applying various COVID-19 re-opening guidelines to the more than 120 U.S. Environmental Protection Agency (EPA) facilities.Methods: A geographic information system boundary was created for each EPA facility encompassing the county where the EPA facility is located and the counties where employees commuted from.
Lisa Baxter, Jeremy Baynes, Anne Weaver, Anne Neale, Timothy Wade, Megan Mehaffey, Danelle Lobdell, Kelly Widener, Wayne Cascio   +8 more
openaire   +3 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Seasonal variation in apparent conductivity and soil salinity at two Narragansett Bay, RI salt marshes [PDF]

PeerJ, 2019
Measurement of the apparent conductivity of salt marsh sediments using electromagnetic induction (EMI) is a rapid alternative to traditional methods of salinity determination that can be used to map soil salinity across a marsh surface.
Richard McKinney, Alana Hanson, Roxanne Johnson, Michael Charpentier   +3 more
doaj   +2 more sources