Results 31 to 40 of about 757,011 (317)

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States

Journal of Epidemiology and Global Health
Purpose Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns.
Timothy J. Wade, Jatin H. Mistry, Swinburne A. J. Augustine, Shannon M. Griffin, Jason Kobylanski, Jennifer Styles, Elizabeth Sams, Edward Hudgens, Megan Kowalcyk, Wesley Cochran, Honorine Ward, Andrey Egorov   +11 more
doaj   +1 more source

Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults

Particle and Fibre Toxicology, 2020
Background Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.
Lauren H. Wyatt, Robert B. Devlin, Ana G. Rappold, Martin W. Case, David Diaz-Sanchez   +4 more
doaj   +1 more source

Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats

Frontiers in Toxicology, 2023
Introduction: Acrolein is a significant component of anthropogenic and wildfire emissions, as well as cigarette smoke. Although acrolein primarily deposits in the upper respiratory tract upon inhalation, patterns of site-specific injury in nasal versus ...
Devin I. Alewel, Thomas W. Jackson, Katherine M. Rentschler, Mette C. Schladweiler, Anna Astriab-Fisher, Stephen H. Gavett, Paul A. Evansky, Urmila P. Kodavanti   +7 more
doaj   +1 more source

Wildlife Exposure Factors Handbook, Appendix: Literature Review Database, Volume II of II [PDF]

, 1993
This Appendix is intended to accompany the Wildlife Exposure Factors Handbook (hereafter referred to as the Handbook) and should be used only by individuals familiar with the Handbook.
Agency, United States Environmental Protection
core   +1 more source

Organizing the interface—Plasma membrane architecture and receptor dynamics in virus‐cell interactions

FEBS Letters, EarlyView.
Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
wiley   +1 more source

Phthalate exposure and female reproductive and developmental outcomes: a systematic review of the human epidemiological evidence

Environment International, 2019
Objective: We performed a systematic review of the epidemiology literature to identify the female reproductive and developmental effects associated with phthalate exposure.
Elizabeth G. Radke, Barbara S. Glenn, Joseph M. Braun, Glinda S. Cooper   +3 more
doaj   +1 more source

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Greater residential greenness is associated with reduced epigenetic aging in adults

Scientific Reports
Potential pathways linking urban green spaces to improved health include relaxation, stress alleviation, and improved immune system functioning. Epigenetic age acceleration (EAA) is a composite biomarker of biological aging based on DNA methylation ...
Andrey I. Egorov, Shannon M. Griffin, Jo Klein, Wei Guo, Jennifer N. Styles, Jason Kobylanski, Mark S. Murphy, Elizabeth Sams, Edward E. Hudgens, Timothy J. Wade   +9 more
doaj   +1 more source

Watershed analysis of urban stormwater contaminant 6PPD-Quinone hotspots and stream concentrations using a process-based ecohydrological model

Frontiers in Environmental Science
Coho salmon (Oncorhynchus kisutch) are highly sensitive to 6PPD-Quinone (6PPD-Q). Details of the hydrological and biogeochemical processes controlling spatial and temporal dynamics of 6PPD-Q fate and transport from points of deposition to receiving ...
Jonathan J. Halama, Robert B. McKane, Bradley L. Barnhart, Paul P. Pettus, Allen F. Brookes, Angela K. Adams, Catherine K. Gockel, Kevin S. Djang, Vivian Phan, Sonali M. Chokshi, James J. Graham, Zhenyu Tian, Zhenyu Tian, Katherine T. Peter, Katherine T. Peter, Edward P. Kolodziej, Edward P. Kolodziej, Edward P. Kolodziej   +17 more
doaj   +1 more source