Results 31 to 40 of about 12,745,617 (300)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Salivary Antibody Responses to Potentially Waterborne and Environmentally Transmitted Infections Among Two Tribal Nations in the Southwest United States

Journal of Epidemiology and Global Health
Purpose Tribal Nations disproportionately lack access to safe drinking water and can be adversely affected by other water quality and environmental concerns.
Timothy J. Wade, Jatin H. Mistry, Swinburne A. J. Augustine, Shannon M. Griffin, Jason Kobylanski, Jennifer Styles, Elizabeth Sams, Edward Hudgens, Megan Kowalcyk, Wesley Cochran, Honorine Ward, Andrey Egorov   +11 more
doaj   +1 more source

Low levels of fine particulate matter increase vascular damage and reduce pulmonary function in young healthy adults

Particle and Fibre Toxicology, 2020
Background Fine particulate matter (PM2.5) related mild inflammation, altered autonomic control of cardiovascular function, and changes to cell function have been observed in controlled human exposure studies.
Lauren H. Wyatt, Robert B. Devlin, Ana G. Rappold, Martin W. Case, David Diaz-Sanchez   +4 more
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Differential transcriptomic alterations in nasal versus lung tissue of acrolein-exposed rats

Frontiers in Toxicology, 2023
Introduction: Acrolein is a significant component of anthropogenic and wildfire emissions, as well as cigarette smoke. Although acrolein primarily deposits in the upper respiratory tract upon inhalation, patterns of site-specific injury in nasal versus ...
Devin I. Alewel, Thomas W. Jackson, Katherine M. Rentschler, Mette C. Schladweiler, Anna Astriab-Fisher, Stephen H. Gavett, Paul A. Evansky, Urmila P. Kodavanti   +7 more
doaj   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Greater residential greenness is associated with reduced epigenetic aging in adults

Scientific Reports
Potential pathways linking urban green spaces to improved health include relaxation, stress alleviation, and improved immune system functioning. Epigenetic age acceleration (EAA) is a composite biomarker of biological aging based on DNA methylation ...
Andrey I. Egorov, Shannon M. Griffin, Jo Klein, Wei Guo, Jennifer N. Styles, Jason Kobylanski, Mark S. Murphy, Elizabeth Sams, Edward E. Hudgens, Timothy J. Wade   +9 more
doaj   +1 more source

Watershed analysis of urban stormwater contaminant 6PPD-Quinone hotspots and stream concentrations using a process-based ecohydrological model

Frontiers in Environmental Science
Coho salmon (Oncorhynchus kisutch) are highly sensitive to 6PPD-Quinone (6PPD-Q). Details of the hydrological and biogeochemical processes controlling spatial and temporal dynamics of 6PPD-Q fate and transport from points of deposition to receiving ...
Jonathan J. Halama, Robert B. McKane, Bradley L. Barnhart, Paul P. Pettus, Allen F. Brookes, Angela K. Adams, Catherine K. Gockel, Kevin S. Djang, Vivian Phan, Sonali M. Chokshi, James J. Graham, Zhenyu Tian, Zhenyu Tian, Katherine T. Peter, Katherine T. Peter, Edward P. Kolodziej, Edward P. Kolodziej, Edward P. Kolodziej   +17 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Relationships among the Energy, Emergy and Money Flows of the United States from 1900 to 2011

Frontiers in Energy Research, 2014
Energy Systems Language models of the resource base for the U.S. economy and of economic exchange were used, respectively, (1) to show how energy consumption and emergy use contribute to real and nominal GDP and (2) to propose a model of coupled flows ...
Daniel Elliott Campbell, Hongfang eLu, Henry Allen Walker   +2 more
doaj   +1 more source